Synthesis and antibacterial activity of 2-aryl-2, 5-dibydro-3(3H)-oxo-pyridazino[4,3-b]indole-4-carboxylic acids

被引：16

作者：

Palluotto, F ^{[1
]}

Carotti, A ^{[1
]}

Casini, G ^{[1
]}

Ferappi, M ^{[1
]}

Rosato, A ^{[1
]}

Vitali, C ^{[1
]}

Campagna, F ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Farmacochim, I-70126 Bari, Italy

来源：

FARMACO | 1999年 / 54卷 / 03期

关键词：

pyridazino[4,3-b]indolones; structure-antibacterial activity relationships; antibacterial activity; antifungal activity;

D O I：

10.1016/S0014-827X(99)00021-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The in vitro antibacterial and antifungal activities of a series of pyridazinoindolonic acids II against some selected representative of Gram-positive, Gram-negative bacteria and fungi have been investigated. Some interesting observations among the structural features necessary for high antibacterial activity are presented and discussed. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：191 / 194

页数：4

共 8 条

[1]

BARRAJA P, 1997, P 1 IT SWISS M MED C, P164

[2]

Campagna F, 1993, Bioorg Med Chem, V1, P437, DOI 10.1016/S0968-0896(00)82154-9

[3]

CHU DTW, 1991, ADV DRUG RES, V21, P40

[4]

MITSUHASHI S, 1992, PROGR DRUG RES, V38, P9

[5] Structure-activity relationships of 2-aryl-2,5-dihydropyridazino[4,3-b]indol-3(3H)-ones at the benzodiazepine receptor [J].

Palluotto, F ;

Carotti, A ;

Casini, G ;

Campagna, F ;

Genchi, G ;

Rizzo, M ;

DeSarro, GB .

BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (12) :2091-2104

[6]

Rosen T, 1990, Prog Med Chem, V27, P235, DOI 10.1016/S0079-6468(08)70293-5

[7] SYNTHESIS OF 1,4-DIHYDRO-4-OXOPYRIDAZINO[1,6-A]INDOLE-3-CARBOXYLIC ACIDS AND 1,4-DIHYDRO-4-OXOPYRIDO[3',2'/4,5]PYRROLO[1,2-B]-PYRIDAZINE-3-CARBOXYLIC ACIDS AS POTENTIAL ANTIBACTERIAL AGENTS [J].

RUXER, JM ;

LACHOUX, C ;

OUSSET, JB ;

TORREGROSA, JL ;

MATTIODA, G .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (06) :1561-1568

[8]

SHADOMY S, 1980, MANUAL CLIN MICROBIO, P467

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