A novel dibenzoazacyclooctyne precursor in regioselective copper-free click chemistry. An innovative 3-step synthesis

被引：18
作者：
Starke, Frank [1 ]
Walther, Martin [1 ]
Pietzsch, Hans-Juergen [1 ]
机构：
[1] Forschungszentrum Dresden Rossendorf, Inst Radiopharm, Postfach 510119, D-01314 Dresden, Germany
来源：
ARKIVOC | 2010年
关键词：
Bioorthogonal; cyclooctyne; azides; click chemistry; AZIDE;
D O I：
10.3998/ark.5550190.0011.b28
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel carboxylic acid substituted dibenzoazacyclooctyne precursor has been synthesized using a fast and innovative three-step synthesis. It can be easily converted into the corresponding alkyne through UV-irradiation. Due to its fast and regioselective reaction with azides, the alkyne is a promising agent for copper-free "click chemistry". The second order reaction rate constant was determined by H-1-NMR.
引用
收藏
页码：350 / 359
页数：10
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