Synthesis of Nano-Polymer Supported on Nano-Hydrogel Chitosan Base and Its Application for DOX Delivery

In this study, a nanogel-hydrogel hybrid was synthesized to improve drug delivery system performance. First, poly (acrylic acid-N-isopropylacrylamide) nanoparticles were synthesized using acrylic acid, N-isopropylacrylamide, sodium dodecyl sulfate, and MBA in the presence of APS as a radical initiator. Then the synthesized (A-N) nanogel was added to a solution of chitosan in acetic acid and (A-N) nanogel/ CTS-A hydrogel was synthesized in the presence of AA, MBA and ASP. (A-N) nanogel/ CTS-A hydrogel was characterized by IR, SEM, EDX, TEM, DLS, TGA, DTG and BET techniques. Doxorubicin (DOX) solution was used to evaluate drug loading capacity and the amount of drug-loaded was calculated using UV analysis. Drug release behavior was investigated by placing DOX-loaded (A-N) nanogel/ CTS-A at different temperature and pH ranges. Our research indicated the drug release for both carriers was controlled by diffusion mechanism but, increasing of temperature had not influenced the drug release mechanism. However, this study suggests that by trapping nanoparticles in a hydrogel system, drug carriers with higher absorption capacity and slower kinetic release can be created.