In vitro SUSCEPTIBILITY TESTING OF DERMATOPHYTES ISOLATED IN GOIANIA, BRAZIL, AGAINST FIVE ANTIFUNGAL AGENTS BY BROTH MICRODILUTION METHOD

被引：58

作者：

Araujo, Crystiane Rodrigues ^{[1
]}

Miranda, Karla Carvalho ^{[1
]}

Lisboa Fernandes, Orionalda de Fatima ^{[1
]}

Soares, Ailton Jose ^{[1
]}

Rodrigues Silva, Maria do Rosario ^{[1
]}

机构：

[1] Univ Fed Goias, Inst Patol Trop & Saude Publ, BR-74605050 Goiania, Go, Brazil

来源：

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2009年 / 51卷 / 01期

关键词：

Dermatophytes; Broth microdilution method; Minimal Inhibitory Concentration; TRICHOPHYTON-RUBRUM; MENTAGROPHYTES; TERBINAFINE; STRAINS; DRUGS; RESISTANCE;

D O I：

10.1590/S0036-46652009000100002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The antifungal activities of fluconazole, itraconazole, ketoconazole, terbinafine and griseofulvin were tested by broth microdilution technique, against 60 dermatophytes isolated from nail or skin specimens from Goiania city patients, Brazil. In this study, the microtiter plates were incubated at 28 degrees C allowing a reading of the minimal inhibitory concentration ( MIC) after four days of incubation for Trichophyton mentagrophytes and five days for T. rubrum and Microsporum canis. Most of the dermatophytes had uniform patterns of susceptibility to the antifungal agents tested. Low MIC values as 0.03 mu g/mL were found for 33.3%, 31.6% and 15% of isolates for itraconazole, ketoconazole and terbinafine, respectively.

引用

页码：9 / 12

页数：4

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