Self-Assembled Dual Dye-Doped Nanosized Micelles for High-Contrast Up-Conversion Bioimaging

被引：64

作者：

Mattiello, Sara ^{[1
]}

Monguzzi, Angelo ^{[1
]}

Pedrini, Jacopo ^{[1
]}

Sassi, Mauro ^{[1
]}

Villa, Chiara ^{[2
]}

Torrente, Yvan ^{[2
]}

Marotta, Roberto ^{[3
]}

Meinardi, Francesco ^{[1
]}

Beverina, Luca ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dipartimento Sci Mat, Via R Cozzi 55, I-20125 Milan, Italy

[2] Univ Milano Bicocca, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Dino Ferrari, Dept Pathophysiol & Transplantat, Via F Sforza 35, I-20122 Milan, Italy

[3] Ist Italiano Tecnol, Via Morego 30, I-16163 Genoa, Italy

来源：

ADVANCED FUNCTIONAL MATERIALS | 2016年 / 26卷 / 46期

关键词：

TRIPLET-TRIPLET ANNIHILATION; LOW-POWER; SUBSOLAR IRRADIANCE; ENERGY-TRANSFER; EXCITED-STATE; NANOCAPSULES; RED; EXCITATION; BILAYER; IR;

D O I：

10.1002/adfm.201603303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sensitized triplet-triplet annihilation based photon up-conversion (TTA-UC) greatly improves the scope and applicability of fluorescence bioimaging by enabling anti-Stokes detection at low powers, thus eliminating the background autofluorescence and limiting the potential damage of the living tissues. Here the authors present a facile, one-step protocol to prepare dual dye-doped, TTA-UC active nanomicelles starting from the commercially available surfactant Kolliphor EL, a component of several FDA approved preparations. These nanosized micelles show an unprecedented up-conversion yield of 6.5% under 0.1 W cm(-2) excitation intensity in an aqueous, non-deaerated dispersion. The supramolecular architecture obtained preserves the embedded dyes from oxygen quenching, allowing satisfactory anti-Stokes fluorescence imaging of 3T3 cells. This is the first example of efficient multicomponent up-converters prepared using highly biocompatible materials approved by the international authority, paving the way for the development of new complex and multifunctional materials for advanced theranostics.

引用

页码：8447 / 8454

页数：8

共 58 条

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