Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel radiosensitizer

被引：18
|
作者：
Morita, Kenta [1 ]
Miyazaki, Serika [2 ]
Numako, Chiya [2 ]
Ikeno, Shinya [3 ]
Sasaki, Ryohei [4 ]
Nishimura, Yuya [5 ]
Ogino, Chiaki [1 ]
Kondo, Akihiko [1 ,5 ]
机构：
[1] Kobe Univ, Grad Sch Engn, Dept Chem Sci & Engn, Nada Ku, Rokkodaicho 1-1, Kobe, Hyogo 6578501, Japan
[2] Chiba Univ, Grad Sch Sci, Inage Ku, Chiba, Japan
[3] Kyushu Inst Technol, Grad Sch Life Sci & Syst Engn, Wakamatsu Ku, Kitakyushu, Fukuoka, Japan
[4] Kobe Univ, Div Radiat Oncol, Grad Sch Med, Chuou Ku, Kobe, Hyogo, Japan
[5] Kobe Univ, Org Adv Sci & Technol, Nada Ku, Kobe, Hyogo, Japan
来源：
FREE RADICAL RESEARCH | 2016年 / 50卷 / 12期
基金：
日本科学技术振兴机构;
关键词：
Titanium dioxide; nanoparticles; hydrogen peroxide; radiation therapy; reactive oxygen species; radiosensitizer; HYDROGEN-PEROXIDE; METHYLENE-BLUE; CANCER-CELLS; RADIOTHERAPY; RADIATION; DEGRADATION; HYPOXIA; LIGHT; MODEL;
D O I：
10.1080/10715762.2016.1241879
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An induction of polyacrylic acid-modified titanium dioxide with hydrogen peroxide nanoparticles (PAA-TiO2/H2O2 NPs) to a tumor exerted a therapeutic enhancement of X-ray irradiation in our previous study. To understand the mechanism of the radiosensitizing effect of PAA-TiO2/H2O2 NPs, analytical observations that included DLS, FE-SEM, FT-IR, XAFS, and Raman spectrometry were performed. In addition, highly reactive oxygen species (hROS) which PAA-TiO2/H2O2 NPs produced with X-ray irradiation were quantified by using a chemiluminescence method and a EPR spin-trapping method. We found that PAA-TiO2/H2O2 NPs have almost the same characteristics as PAA-TiO2. Surprisingly, there were no significant differences in hROS generation. However, the existence of H2O2 was confirmed in PAA-TiO2/H2O2 NPs, because spontaneous hROS production was observed w/o X-ray irradiation. In addition, PAA-TiO2/H2O2 NPs had a curious characteristic whereby they absorbed H2O2 molecules and released them gradually into a liquid phase. Based on these results, the H2O2 was continuously released from PAA-TiO2/H2O2 NPs, and then released H2O2 assumed to be functioned indirectly as a radiosensitizing factor.
引用
收藏
页码：1319 / 1328
页数：10
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