Physical activity, body mass index, and brain atrophy in Alzheimer's disease

被引：50

作者：

Boyle, Christina P. ^{[1
]}

Raji, Cyrus A. ^{[1
,8
]}

Erickson, Kirk I. ^{[9
]}

Lopez, Oscar L. ^{[10
]}

Becker, James T. ^{[9
,10
,11
]}

Gach, H. Michael ^{[12
]}

Longstreth, W. T., Jr. ^{[13
,14
]}

Teverovskiy, Leonid ^{[11
]}

Kuller, Lewis H. ^{[15
]}

Carmichael, Owen T. ^{[16
]}

Thompson, Paul M. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Univ So Calif, Imaging Genet Ctr, Los Angeles, CA USA

[2] Univ So Calif, Keck USC Sch Med, Dept Neurol, Los Angeles, CA USA

[3] Univ So Calif, Keck USC Sch Med, Dept Psychiat, Los Angeles, CA USA

[4] Univ So Calif, Dept Pediat, Keck USC Sch Med, Los Angeles, CA 90089 USA

[5] Univ So Calif, Keck USC Sch Med, Dept Engn, Los Angeles, CA 90089 USA

[6] Univ So Calif, Keck USC Sch Med, Dept Radiol, Los Angeles, CA 90089 USA

[7] Univ So Calif, Dept Ophthalmol, Keck USC Sch Med, Los Angeles, CA 90089 USA

[8] UCLA Sch Med, Dept Radiol, Los Angeles, CA USA

[9] Univ Pittsburgh, Dept Psychol, Sch Med, Pittsburgh, PA 15260 USA

[10] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[11] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[12] Univ Pittsburgh, Sch Med, Dept Radiol, Pittsburgh, PA USA

[13] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[14] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[15] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[16] Pennington Biomed Res Ctr, Biomed Imaging Ctr, Baton Rouge, LA 70808 USA

来源：

NEUROBIOLOGY OF AGING | 2015年 / 36卷

关键词：

Physical activity; Body mass index; Alzheimer's; Tensor-based morphometry; MILD COGNITIVE IMPAIRMENT; GRAY-MATTER VOLUME; CARDIOVASCULAR HEALTH; AEROBIC EXERCISE; OLDER-ADULTS; DEMENTIA; DECLINE; RISK; PERFORMANCE; PREVALENCE;

D O I：

10.1016/j.neurobiolaging.2014.05.036

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The purpose of this study was to use a novel imaging biomarker to assess associations between physical activity (PA), body mass index (BMI), and brain structure in normal aging, mild cognitive impairment, and Alzheimer's dementia. We studied 963 participants (mean age: 74.1 +/- 4.4 years) from the multisite Cardiovascular Health Study including healthy controls (n = 724), Alzheimer's dementia patients (n = 104), and people with mild cognitive impairment (n = 135). Volumetric brain images were processed using tensor-based morphometry to analyze regional brain volumes. We regressed the local brain tissue volume on reported PA and computed BMI, and performed conjunction analyses using both variables. Covariates included age, sex, and study site. PA was independently associated with greater whole brain and regional brain volumes and reduced ventricular dilation. People with higher BMI had lower whole brain and regional brain volumes. A PA-BMI conjunction analysis showed brain preservation with PA and volume loss with increased BMI in overlapping brain regions. In one of the largest voxel-based cross-sectional studies to date, PA and lower BMI may be beneficial to the brain across the spectrum of aging and neurodegeneration. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：S194 / S202

页数：9

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