Circadian rhythm of urinary potassium excretion in patients with CKD

被引：7

作者：

Miura, Toshiyuki ^{[1
]}

Fukuda, Michio ^{[1
]}

Naito, Takehiro ^{[1
]}

Togawa, Hiroyuki ^{[1
]}

Sato, Ryo ^{[1
]}

Sasagawa, Yuji ^{[1
]}

Tomonari, Tatsuya ^{[1
]}

Kato, Yoko ^{[1
]}

Mizuno, Masashi ^{[1
]}

Ono, Minamo ^{[1
]}

Ichikawa, Tadashi ^{[1
]}

Shirasawa, Yuichi ^{[1
]}

Ito, Akinori ^{[1
]}

Yoshida, Atsuhiro ^{[1
]}

Kimura, Genjiro ^{[1
]}

机构：

[1] Nagoya City Univ, Dept Cardiorenal Med & Hypertens, Grad Sch Med Sci, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

CLINICAL NEPHROLOGY | 2012年 / 78卷 / 03期

基金：

日本学术振兴会;

关键词：

blood pressure; circadian rhythm; chronic kidney disease; urinary sodium; urinary potassium; NOCTURNAL BLOOD-PRESSURE; HYPERTENSION; SODIUM; MANAGEMENT; NONDIPPER; DIPPER; NATRIURESIS; GUIDELINES; MECHANISMS; DISEASE;

D O I：

10.5414/CN107399

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: We previously reported in patients with chronic kidney disease (CKD) that the circadian rhythms of blood pressure (BP) and urinary sodium excretion were both impaired into non-dipper pattern as renal function deteriorated. However, the circadian rhythm of urinary potassium excretion has not been studied in relation to renal dysfunction. Methods: BP and urinary excretion rates of sodium (UNaV) and potassium (UKV) were evaluated for day-time and night-time to estimate their circadian rhythms in 83 subjects with CKD. Results: As renal function deteriorated, night/day ratios of UNaV and UKV were both increased. Night/day ratio of UKV was positively correlated with night/day ratio of UNaV (r = 0.60, p < 0.0001). Multiple regression analysis (R-2 = 0.37, p < 0.0001) revealed that night/day ratio of UKV was determined independently by the night/day ratio of UNaV (r = -0.55, p < 0.0001), rather than renal function or night/day ratio of BP. Conclusions: Circadian rhythm of natriuresis was regulated by renal function and night/day ratio of BP. On the other hand, the circadian rhythm of urinary potassium excretion was primarily determined by neither renal function nor BP, but was correlated with that of urinary sodium excretion.

引用

页码：169 / 173

页数：5

共 24 条

[1] Ethnic differences in urine concentration: Possible relationship to blood pressure [J].