Convenient synthesis of D- and L-xylo-1,2,3,4-alkane tetrols from a D-gluco-configured common building block

被引：11

作者：

Borkar, Santosh Ramdas ^{[1
]}

Manjunath, Beedimane Narayana ^{[1
]}

Balasubramaniam, Sivaraman ^{[1
]}

Aidhen, Indrapal Singh ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

CARBOHYDRATE RESEARCH | 2012年 / 358卷

关键词：

Guggultetrols; Wittig olefination; Grignard reaction; Barton-McCombie deoxygenation; COMMIPHORA-MUKUL; GUGGULTETROLS; DERIVATIVES;

D O I：

10.1016/j.carres.2012.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-gluco-Configured building block derived from D-(+)-gluconolactone has served as a common chiral template for the synthesis of enantiopure D-and L-xylo-configured 1,2,3,4-alkane tetrols. This has enabled synthesis of medicinally important guggultetrols and their enantiomers from a common starting point. Wittig and Grignard reactions are the key steps used for the incorporation of lipophilic chain. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：23 / 30

页数：8

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