The Clinical Significance of 25OH-Vitamin D Status in Celiac Disease

被引:63
作者
Lerner, Aaron [1 ,2 ,4 ]
Shapira, Yinon [3 ]
Agmon-Levin, Nancy [3 ,4 ]
Pacht, Avi [2 ]
Shor, Dana Ben-Ami [3 ,4 ]
Marcus Lopez, Hoyos [5 ]
Sanchez-Castanon, Maria [5 ]
Shoenfeld, Yehuda [3 ,4 ]
机构
[1] Carmel Hosp, Pediat Gastroenterol & Nutr Unit, IL-34362 Haifa, Israel
[2] Technion Israel Inst Technol, Carmel Med Ctr, B Rappaport Sch Med, Pediat Gastroenterol & Nutr Unit, Haifa, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Zabludowicz Ctr Autoimmune Dis, IL-69978 Tel Aviv, Israel
[4] Tel Aviv Univ, Sackler Fac Med, Dept Med B, Sheba Med Ctr, IL-69978 Tel Aviv, Israel
[5] Hosp Univ Marques de Valdecilla, Serv Inmunol, Santander 39008, Spain
关键词
Celiac disease; Vitamin D; Children; Adults; Autoimmunity; Israel; Spain; VITAMIN-D DEFICIENCY; BONE-MINERAL DENSITY; 1,25-DIHYDROXYVITAMIN D-3; TISSUE TRANSGLUTAMINASE; ENDOMYSIAL ANTIBODIES; HELICOBACTER-PYLORI; DENDRITIC CELLS; NOD MICE; D ANALOG; CHILDREN;
D O I
10.1007/s12016-010-8237-8
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Reduced bone mineral density is frequently found especially in adult celiac disease (CD) and dietary guidelines favor vitamin D supplementation in adults and children with CD. Vitamin D serum levels were investigated in CD populations in order to challenge its routine supplementation. Israeli (61), Spanish (59), CD children (groups 1 and 5, respectively) were compared to children with nonspecific abdominal pain (56), their parents (84) and Spanish adult CD patients (22) (group 2, 3, 4, respectively). 25(OH)-vitamin D was checked by LIAISON chemiluminescent immunoassays. Groups 5 and 1 had the highest levels compared to groups 4 and 3 with the lowest levels. The levels in groups 1 and 2 were comparable. Concerning 25(OH)-vitamin D sera levels, only the difference between group 5 and 4 was statistically significant (30.3 +/- 12.3 and 20.2 +/- 10.5 ng/ml, respectively = 0.003). When vitamin D was splitted above and below 20 ng/ml level, 54.5% of Spanish adult CD had vitamin D deficiency compared to 16.9% of the local CD children ( = 0.001). 29.6% of group 2 had deficient levels compared to their parents with 50% ( = 0.019). In conclusion, Vitamin D sera levels negatively correlate with age. Thus, mainly adult CD population should be assessed for vitamin D levels and supplemented accordingly.
引用
收藏
页码:322 / 330
页数:9
相关论文
共 99 条
[1]  
ABE J, 1990, J NUTR SCI VITAMINOL, V36, P21, DOI 10.3177/jnsv.36.21
[2]   Pharmacological induction of tolerogenic dendritic cells and regulatory T cells [J].
Adorini, L ;
Giarratana, N ;
Penna, G .
SEMINARS IN IMMUNOLOGY, 2004, 16 (02) :127-134
[3]   Control of autoimmune diseases by the vitamin D endocrine system [J].
Adorini, Luciano ;
Penna, Giuseppe .
NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2008, 4 (08) :404-412
[4]  
Adorini Luciano, 2009, Handb Exp Pharmacol, P251, DOI 10.1007/978-3-540-71029-5_12
[5]   Low vitamin D levels in outpatient postmenopausal women from a rheumatology clinic in Madrid, Spain:: Their relationship with bone mineral density [J].
Aguado, P ;
del Campo, MT ;
Garcés, MV ;
González-Casaús, ML ;
Bernad, M ;
Gijón-Baños, J ;
Mola, EM ;
Torrijos, A ;
Martínez, ME .
OSTEOPOROSIS INTERNATIONAL, 2000, 11 (09) :739-744
[6]   Vitamin D: The alternative hypothesis [J].
Albert, Paul J. ;
Proal, Amy D. ;
Marshall, Trevor G. .
AUTOIMMUNITY REVIEWS, 2009, 8 (08) :639-644
[7]   Vitamin D and autoimmunity: New aetiological and therapeutic considerations [J].
Arnson, Yoav ;
Amital, Howard ;
Shoenfeld, Yehuda .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) :1137-1142
[8]   Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes [J].
Bailey, Rebecca ;
Cooper, Jason D. ;
Zeitels, Lauren ;
Smyth, Deborah J. ;
Yang, Jennie H. M. ;
Walker, Neil M. ;
Hyppoenen, Elina ;
Dunger, David B. ;
Ramos-Lopez, Elizabeth ;
Badenhoop, Klaus ;
Nejentsev, Sergey ;
Todd, John A. .
DIABETES, 2007, 56 (10) :2616-2621
[9]   The pathophysiology of bone disease in gastrointestinal disease [J].
Bernstein, CN ;
Leslie, WD .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2003, 15 (08) :857-864
[10]  
BHALLA AK, 1984, J IMMUNOL, V133, P1748