A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection

被引：178

作者：

Guner, Hasan ^{[1
]}

Ozgur, Erol ^{[1
]}

Kokturk, Guzin ^{[2
]}

Celik, Mehmet ^{[3
]}

Esen, Elif ^{[2
]}

Topal, Ahmet E. ^{[1
]}

Ayas, Sencer ^{[4
]}

Uludag, Yildiz ^{[2
]}

Elbuken, Caglar ^{[1
]}

Dana, Aykutlu ^{[1
]}

机构：

[1] Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM, TR-06800 Ankara, Turkey

[2] Sci & Technol Res Council Turkey TUBITAK, UEKAE BILGEM, TR-41470 Gebze, Kocaeli, Turkey

[3] Middle East Tech Univ, Dept Comp Engn, TR-06800 Ankara, Turkey

[4] Stanford Sch Med, Dept Radiol, Canary Ctr Stanford Canc Early Detect, Palo Alto, CA 94304 USA

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 239卷

关键词：

Plasmonics; Surface plasmon resonance imaging; Optical discs; Mobile sensing; Biosensors; Optical sensor; GAS-DETECTION; CELL PHONE; BIOSENSOR; FILMS; SENSORS; LAYER;

D O I：

10.1016/j.snb.2016.08.061

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We demonstrate a surface plasmon resonance imaging platform integrated with a smartphone to be used in the field with high-throughput biodetection. Inexpensive and disposable SPR substrates are produced by metal coating of commercial Blu-ray discs. A compact imaging apparatus is fabricated using a 3D printer which allows taking SPR measurements from more than 20.000 individual pixels. Real-time bulk refractive index change measurements yield noise equivalent refractive index changes as low as 4.12 x 10(-5) RIU which is comparable with the detection performance of commercial instruments. As a demonstration of a biological assay, we have shown capture of mouse IgG antibodies by immobilized layer of rabbit anti-mouse (RAM) IgG antibody with nanomolar level limit of detection. Our approach in miniaturization of SPR biosensing in a cost-effective manner could enable realization of portable SPR measurement systems and kits for point-of-care applications. (C) 2016 Published by Elsevier B.V.

引用

页码：571 / 577

页数：7

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