Cushing's syndrome

被引:976
作者
Newell-Price, J [1 ]
Bertagna, X
Grossman, AB
Nieman, LK
机构
[1] Univ Sheffield, No Gen Hosp, Div Clin Sci, Sheffield S5 7AU, S Yorkshire, England
[2] Royal Hallamshire Hosp, Dept Endocrinol, Sheffield S10 2JF, S Yorkshire, England
[3] Univ Paris 05, Fac Med Rene Descartes, INSERM, U567,Inst Cochin,Dept Endocrinol, Paris, France
[4] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Dept Endocrinol, London, England
[5] NICHHD, Reprod Endocrinol & Med Branch, NIH, Bethesda, MD 20891 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0140-6736(06)68699-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.
引用
收藏
页码:1605 / 1617
页数:13
相关论文
共 198 条
  • [1] Ambrosi B, 1990, Clin Endocrinol (Oxf), V33, P809
  • [2] Effects of chronic administration of PPAR-γ ligand rosiglitazone in Cushing's disease
    Ambrosi, B
    Dall'Asta, C
    Cannavò, S
    Libé, R
    Vigo, T
    Epaminonda, P
    Chiodini, L
    Ferrero, S
    Trimarchi, F
    Arosio, M
    Beck-Peccoz, P
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2004, 151 (02) : 173 - 178
  • [3] Cushing syndrome due to ectopic adrenocorticotropic hormone secretion
    Aniszewski, JP
    Young, WF
    Thompson, GB
    Grant, CS
    van Heerden, JA
    [J]. WORLD JOURNAL OF SURGERY, 2001, 25 (07) : 934 - 940
  • [4] Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro
    Arlt, W
    Dahia, PLM
    Callies, F
    Nordmeyer, JP
    Allolio, B
    Grossman, AB
    Reincke, M
    [J]. CLINICAL ENDOCRINOLOGY, 1997, 47 (05) : 623 - 627
  • [5] Diagnosis and complications of Cushing's syndrome: A consensus statement
    Arnaldi, G
    Angeli, A
    Atkinson, AB
    Bertagna, X
    Cavagnini, F
    Chrousos, GP
    Fava, GA
    Findling, JW
    Gaillard, RC
    Grossman, AB
    Kola, B
    Lacroix, A
    Mancini, T
    Mantero, F
    Newell-Price, J
    Nieman, LK
    Sonino, N
    Vance, ML
    Giustina, A
    Boscaro, M
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (12) : 5593 - 5602
  • [6] Variable expression of the V1 vasopressin receptor modulates the phenotypic response of steroid-secreting adrenocortical tumors
    Arnaldi, G
    Gasc, JM
    de Keyzer, Y
    Raffin-Sanson, ML
    Perraudin, V
    Kuhn, JM
    Raux-Demay, MC
    Luton, JP
    Clauser, E
    Bertagna, X
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (06) : 2029 - 2035
  • [7] Effectiveness versus efficacy: The limited value in clinical practice of high dose dexamethasone suppression testing in the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome
    Aron, DC
    Raff, H
    Findling, JW
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (06) : 1780 - 1785
  • [8] The Nelson's syndrome... revisited
    Assié G.
    Bahurel H.
    Bertherat J.
    Kujas M.
    Legmann P.
    Bertagna X.
    [J]. Pituitary, 2004, 7 (4) : 209 - 215
  • [9] Long-term remission rates after pituitary surgery for Cushing's disease: the need for long-term surveillance
    Atkinson, AB
    Kennedy, A
    Wiggam, MI
    McCance, DR
    Sheridan, B
    [J]. CLINICAL ENDOCRINOLOGY, 2005, 63 (05) : 549 - 559
  • [10] Detection of adrenocorticotropin-secreting pituitary adenomas by magnetic resonance imaging in children and adolescents with Cushing disease
    Batista, D
    Courkoutsakis, NA
    Oldfield, EH
    Griffin, KJ
    Keil, M
    Patronas, NJ
    Stratakis, CA
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (09) : 5134 - 5140