Effect of primary tumor invasion on treatment and survival in extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: a multicenter study from the China Lymphoma Collaborative Group (CLCG)

被引：24

作者：

Qi, Shu-Nan ^{[1
,2
,3
,4
]}

Xu, Li-Ming ^{[5
]}

Yuan, Zhi-Yong ^{[5
]}

Wu, Tao ^{[6
]}

Zhu, Su-Yu ^{[7
,8
]}

Shi, Mei ^{[9
]}

Su, Hang ^{[10
]}

Wang, Ying ^{[11
]}

He, Xia ^{[12
,13
]}

Zhang, Li-Ling ^{[14
]}

Wu, Gang ^{[14
]}

Qu, Bao-Lin ^{[15
]}

Qian, Li-Ting ^{[16
]}

Hou, Xiao-Rong ^{[17
,18
]}

Zhang, Fu-Quan ^{[17
,18
]}

Zhang, Yu-Jing ^{[19
]}

Zhu, Yuan ^{[20
]}

Cao, Jian-Zhong ^{[21
,22
]}

Lan, Sheng-Min ^{[21
,22
]}

Wu, Jun-Xin ^{[23
]}

Yang, Yong ^{[1
,2
,3
,4
]}

Li, Ye-Xiong ^{[1
,2
,3
,4
]}

机构：

[1] CAMS, Canc Hosp, Natl Canc Ctr, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[2] CAMS, Canc Hosp, Natl Canc Ctr, Dept Radiat Oncol, Beijing 100021, Peoples R China

[3] CAMS, PUMC, Ctr Canc Precis Med, Beijing 100021, Peoples R China

[4] PUMC, Natl Inst Biol Sci, Collaborat Innovat Ctr Canc Med, Beijing 100021, Peoples R China

[5] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China

[6] Guizhou Med Univ, Guizhou Canc Hosp, Affiliated Hosp, Guiyang, Guizhou, Peoples R China

[7] Hunan Canc Hosp, Changsha, Hunan, Peoples R China

[8] Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China

[9] Fourth Mil Med Univ, Xijing Hosp, Xian, Shaanxi, Peoples R China

[10] 307 Hosp, Acad Mil Med Sci, Beijing, Peoples R China

[11] Chongqing Canc Hosp & Canc Inst, Chongqing, Peoples R China

[12] Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China

[13] Jiangsu Inst Canc Res, Nanjing, Jiangsu, Peoples R China

[14] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[15] Chinese Peoples Liberat Army, Gen Hosp, Beijing, Peoples R China

[16] Anhui Med Univ, Affiliated Prov Hosp, Hefei, Anhui, Peoples R China

[17] CAMS, Peking Union Med Coll Hosp, Beijing, Peoples R China

[18] PUMC, Beijing, Peoples R China

[19] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China

[20] Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China

[21] Shanxi Med Univ, Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China

[22] Shanxi Med Univ, Affiliated Canc Hosp, Taiyuan, Shanxi, Peoples R China

[23] Fujian Prov Canc Hosp, Fuzhou, Fujian, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 11期

关键词：

Extranodal; NK; T-cell; lymphoma; prognosis; tumor invasion; T-CELL; CLINICAL-IMPLICATIONS; PROGNOSTIC MODEL; L-ASPARAGINASE; STAGE IE; RADIOTHERAPY; TRIAL; PATTERNS; THERAPY; SMILE;

D O I：

10.1080/10428194.2019.1602265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the effect of primary tumor invasion (PTI) on treatment selection in 1356 patients with extranodal nasal-type NK/T cell lymphoma who received non-anthracycline-based chemotherapy from the updated dataset of China Lymphoma Collaborative Group. 760 (56.0%) patients had PTI. PTI showed most prominent effect in stage I disease, with 5-year overall survival (OS) of 83.0% in PTI-absent patients and 69.5% in PTI-present patients (p < .001). Radiotherapy +/- chemotherapy achieved higher OS in PTI-absent stage I patients (approximately 85%). Either radiotherapy alone or chemotherapy alone was associated with an unfavorable OS in PTI-present patients (approximately 55%). Compared to radiotherapy alone, combined modality treatment improved OS in PTI-present patients (78.3% vs. 56.6%; p = .001) but showed similar OS in PTI-absent patients (85.3% vs. 83.3%; p = .560). These findings were confirmed in multivariate analyses. PTI was a robust prognostic factor and indicator for additional chemotherapy in stage I NKTCL patients.

引用

页码：2669 / 2678

页数：10

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[21] Modern Radiation Therapy for Extranodal Nasal-Type NK/T-cell Lymphoma: Risk-Adapted Therapy, Target Volume, and Dose Guidelines from the International Lymphoma Radiation Oncology Group [J].

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Li, Ye-Xiong ;

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[22] Treatment outcomes of and prognostic factors for definitive radiotherapy with and without chemotherapy for Stage I/II nasal extranodal NK/T-cell lymphoma [J].

Yang, Claire Wen-Chi ;

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Yao, Ming ;

Tang, Jih-Luh ;

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[23] L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type [J].

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Wang, Xiaopei ;

Xie, Yan ;

Lin, Ningjing ;

Xu, Bo ;

Lu, Aiping ;

Li, Jiyou .

ANNALS OF HEMATOLOGY, 2009, 88 (07) :647-652

[24] Chemotherapy combined with high-dose extended-field radiotherapy for stage I extranodal nasal-type natural killer/T-cell lymphoma [J].

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Zhang, Na ;

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[25] The Diagnosis and Management of Extranodal NK/T-Cell Lymphoma, Nasal-Type and Aggressive NK-Cell Leukemia [J].

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[26] Laryngeal Extranodal Nasal-type Natural Killer/T-cell Lymphoma A Clinicopathologic Study of 31 Cases in China [J].

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Tao, Qing ;

Zuo, Zhuo ;

Lin, Xiao-yu ;

Lin, Wei-ping .

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[27] RADIOTHERAPY ALONE WITH CURATIVE INTENT IN PATIENTS WITH STAGE I EXTRANODAL NASAL-TYPE NK/T-CELL LYMPHOMA [J].

Li, Ye-Xiong ;

Wang, Hua ;

Jin, Jing ;

Wang, Wei-Hu ;

Liu, Qing-Feng ;

Song, Yong-Wen ;

Wang, Zhao-Yang ;

Qi, Shu-Nan ;

Wang, Shu-Lian ;

Liu, Yue-Ping ;

Liu, Xin-Fan ;

Yu, Zi-Hao .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (05) :1809-1815

[28] Clinicopathologic and Immunophenotypic Features of Primary Intestinal Extranodal NK/T-Cell Lymphoma, Nasal Type [J].

Fang, Jian-Chen ;

Xia, Zhao-Xia ;

Wang, Chun-Nian ;

Li, Zheng .

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2015, 23 (08) :609-616

[29] Clinical Disparity and Favorable Prognoses for Patients With Waldeyer Ring Extranodal Nasal-type NK/T-cell Lymphoma and Diffuse Large B-cell Lymphoma [J].

Wu, Run-Ye ;

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Wang, Wei-Hu ;

Jin, Jing ;

Wang, Shu-Lian ;

Liu, Yue-Ping ;

Song, Yong-Wen ;

Fang, Hui ;

Ren, Hua ;

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Wang, Zhao-Yang ;

Qi, Shu-Nan ;

Lu, Ning-Ning ;

Chen, Bo ;

Zhang, Xi-Mei ;

Zhou, Li-Qiang ;

Liu, Xin-Fan ;

Yu, Zi-Hao .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2014, 37 (01) :41-46

[30] Association of improved overall survival with decreased distant metastasis following asparaginase-based chemotherapy and radiotherapy for intermediate- and high-risk early-stage extranodal nasal-type NK/T-cell lymphoma: a CLCG study [J].

Zheng, X. ;

He, X. ;

Yang, Y. ;

Liu, X. ;

Zhang, L. L. ;

Qu, B. L. ;

Zhong, Q. Z. ;

Qian, L. T. ;

Hou, X. R. ;

Qiao, X. Y. ;

Wang, H. ;

Zhu, Y. ;

Cao, J. Z. ;

Wu, J. X. ;

Wu, T. ;

Zhu, S. Y. ;

Shi, M. ;

Xu, L. M. ;

Zhang, H. L. ;

Su, H. ;

Song, Y. Q. ;

Zhu, J. ;

Zhang, Y. J. ;

Huang, H. Q. ;

Wang, Y. ;

Chen, F. ;

Yin, L. ;

Qi, S. N. ;

Li, Y. X. .

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