Effect of primary tumor invasion on treatment and survival in extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: a multicenter study from the China Lymphoma Collaborative Group (CLCG)

被引：24

作者：

Qi, Shu-Nan ^{[1
,2
,3
,4
]}

Xu, Li-Ming ^{[5
]}

Yuan, Zhi-Yong ^{[5
]}

Wu, Tao ^{[6
]}

Zhu, Su-Yu ^{[7
,8
]}

Shi, Mei ^{[9
]}

Su, Hang ^{[10
]}

Wang, Ying ^{[11
]}

He, Xia ^{[12
,13
]}

Zhang, Li-Ling ^{[14
]}

Wu, Gang ^{[14
]}

Qu, Bao-Lin ^{[15
]}

Qian, Li-Ting ^{[16
]}

Hou, Xiao-Rong ^{[17
,18
]}

Zhang, Fu-Quan ^{[17
,18
]}

Zhang, Yu-Jing ^{[19
]}

Zhu, Yuan ^{[20
]}

Cao, Jian-Zhong ^{[21
,22
]}

Lan, Sheng-Min ^{[21
,22
]}

Wu, Jun-Xin ^{[23
]}

Yang, Yong ^{[1
,2
,3
,4
]}

Li, Ye-Xiong ^{[1
,2
,3
,4
]}

机构：

[1] CAMS, Canc Hosp, Natl Canc Ctr, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[2] CAMS, Canc Hosp, Natl Canc Ctr, Dept Radiat Oncol, Beijing 100021, Peoples R China

[3] CAMS, PUMC, Ctr Canc Precis Med, Beijing 100021, Peoples R China

[4] PUMC, Natl Inst Biol Sci, Collaborat Innovat Ctr Canc Med, Beijing 100021, Peoples R China

[5] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China

[6] Guizhou Med Univ, Guizhou Canc Hosp, Affiliated Hosp, Guiyang, Guizhou, Peoples R China

[7] Hunan Canc Hosp, Changsha, Hunan, Peoples R China

[8] Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China

[9] Fourth Mil Med Univ, Xijing Hosp, Xian, Shaanxi, Peoples R China

[10] 307 Hosp, Acad Mil Med Sci, Beijing, Peoples R China

[11] Chongqing Canc Hosp & Canc Inst, Chongqing, Peoples R China

[12] Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China

[13] Jiangsu Inst Canc Res, Nanjing, Jiangsu, Peoples R China

[14] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[15] Chinese Peoples Liberat Army, Gen Hosp, Beijing, Peoples R China

[16] Anhui Med Univ, Affiliated Prov Hosp, Hefei, Anhui, Peoples R China

[17] CAMS, Peking Union Med Coll Hosp, Beijing, Peoples R China

[18] PUMC, Beijing, Peoples R China

[19] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China

[20] Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China

[21] Shanxi Med Univ, Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China

[22] Shanxi Med Univ, Affiliated Canc Hosp, Taiyuan, Shanxi, Peoples R China

[23] Fujian Prov Canc Hosp, Fuzhou, Fujian, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 11期

关键词：

Extranodal; NK; T-cell; lymphoma; prognosis; tumor invasion; T-CELL; CLINICAL-IMPLICATIONS; PROGNOSTIC MODEL; L-ASPARAGINASE; STAGE IE; RADIOTHERAPY; TRIAL; PATTERNS; THERAPY; SMILE;

D O I：

10.1080/10428194.2019.1602265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the effect of primary tumor invasion (PTI) on treatment selection in 1356 patients with extranodal nasal-type NK/T cell lymphoma who received non-anthracycline-based chemotherapy from the updated dataset of China Lymphoma Collaborative Group. 760 (56.0%) patients had PTI. PTI showed most prominent effect in stage I disease, with 5-year overall survival (OS) of 83.0% in PTI-absent patients and 69.5% in PTI-present patients (p < .001). Radiotherapy +/- chemotherapy achieved higher OS in PTI-absent stage I patients (approximately 85%). Either radiotherapy alone or chemotherapy alone was associated with an unfavorable OS in PTI-present patients (approximately 55%). Compared to radiotherapy alone, combined modality treatment improved OS in PTI-present patients (78.3% vs. 56.6%; p = .001) but showed similar OS in PTI-absent patients (85.3% vs. 83.3%; p = .560). These findings were confirmed in multivariate analyses. PTI was a robust prognostic factor and indicator for additional chemotherapy in stage I NKTCL patients.

引用

页码：2669 / 2678

页数：10

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