Pharmacoepigenetics in childhood acute lymphoblastic leukemia: involvement of miRNA polymorphisms in hepatotoxicity

被引：11
作者：
Gutierrez-Camino, Angela [1 ]
Umerez, Maitane [1 ]
Santos, Borja [1 ]
Martin-Guerrero, Idoia [1 ]
Garcia de Andoin, Nagore [2 ,3 ]
Sastre, Ana [4 ]
Navajas, Aurora [5 ,6 ]
Astigarraga, Itziar [3 ,5 ,6 ]
Garcia-Orad, Africa [1 ,6 ]
机构：
[1] Univ Basque Country, UPV EHU, Dept Genet Phys Anthropol & Anim Physiol, Leioa, Spain
[2] Univ Hosp Donostia, Dept Pediat, San Sebastian, Spain
[3] Univ Basque Country, UPV EHU, Dept Pediat, Leioa, Spain
[4] Univ Hosp La Paz, Dept Oncohematol, Madrid, Spain
[5] Univ Hosp Cruces, Dept Pediat, Baracaldo, Spain
[6] BioCruces Hlth Res Inst, Baracaldo, Spain
来源：
EPIGENOMICS | 2018年 / 10卷 / 04期
关键词：
chemotherapy; childhood acute lymphoblastic leukemia; hepatotoxicity; methotrexate; miRNAs; SNPs; LIVER-INJURY; GENOME-WIDE; METHOTREXATE; TOXICITY; CHEMOTHERAPY; GENE; SURVIVAL; PHARMACOGENETICS; HOMOCYSTEINE; ASSOCIATION;
D O I：
10.2217/epi-2017-0138
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: Hepatotoxicity is one of the most common drug-related toxicities during the treatment of childhood acute lymphoblastic leukemia (ALL). Many genes involved in liver-specific signaling pathways are tightly controlled by miRNAs, and miRNA function could be modulated by SNPs. As a consequence, we hypothesized that variants inmiRNAs could be associated with drug-induced hepatotoxicity. Methods: We analyzed 213 SNPs in 206 miRNAs in a cohort of 179 children with ALL homogeneously treated. Results: rs2648841 in miR-1208 was the most significant SNP during consolidation phase after false discovery rate correction, probably through an effect on its target genes DHFR, MTR and MTHFR. Conclusion: These results point out the possible involvement of SNPs in miRNAs in toxicity to chemotherapy in children with ALL.
引用
收藏
页码：409 / 417
页数：9
相关论文
共 35 条
[11]   PNPLA3 rs738409 and Hepatotoxicity in Children With B-cell Acute Lymphoblastic Leukemia: A Validation Study in a Spanish Cohort [J].
Gutierrez-Camino, A. ;
Martin-Guerrero, I. ;
Garcia-Orad, A. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 102 (06) :906-906
[12]   The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia [J].
Gutierrez-Camino, Angela ;
Oosterom, Natanja ;
den Hoed, Marissa A. H. ;
Lopez-Lopez, Elixabet ;
Martin-Guerrero, Idoia ;
Pluijm, Saskia M. F. ;
Pieters, Rob ;
de Jonge, Robert ;
Tissing, Wim J. E. ;
Heil, Sandra G. ;
Garcia-Orad, Africa ;
van den Heuvel-Eibrink, Marry M. .
PHARMACOGENETICS AND GENOMICS, 2017, 27 (08) :303-306
[13]   Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis [J].
Iorga, Andrea ;
Dara, Lily ;
Kaplowitz, Neil .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (05)
[14]   MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia [J].
Iparraguirre, Leire ;
Gutierrez-Camino, Angela ;
Umerez, Maitane ;
Martin-Guerrero, Idoia ;
Astigarraga, Itziar ;
Navajas, Aurora ;
Sastre, Ana ;
Garcia de Andoin, Nagore ;
Garcia-Orad, Africa .
PHARMACOGENETICS AND GENOMICS, 2016, 26 (11) :517-525
[15]   Childhood cancer survival: A report from the United Kingdom Childhood Cancer Study [J].
Johnston, W. Thomas ;
Lightfoot, Tracy J. ;
Simpson, Jill ;
Roman, Eve .
CANCER EPIDEMIOLOGY, 2010, 34 (06) :659-666
[16]  
Kotur N, 2012, PHARMACOGENOMICS, V13, P283, DOI [10.2217/PGS.11.153, 10.2217/pgs.11.153]
[17]   Polymorphisms of genes controlling homocysteine levels and IQ score following the treatment for childhood ALL [J].
Krajinovic, M ;
Robaey, P ;
Chiasson, S ;
Lemieux-Blanchard, E ;
Rouillard, M ;
Primeau, M ;
Bournissen, FG ;
Moghrabi, A .
PHARMACOGENOMICS, 2005, 6 (03) :293-302
[18]   Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia [J].
Krajinovic, M. ;
Elbared, J. ;
Drouin, S. ;
Bertout, L. ;
Rezgui, A. ;
Ansari, M. ;
Raboisson, M-J ;
Lipshultz, S. E. ;
Silverman, L. B. ;
Sallan, S. E. ;
Neuberg, D. S. ;
Kutok, J. L. ;
Laverdiere, C. ;
Sinnett, D. ;
Andelfinger, G. .
PHARMACOGENOMICS JOURNAL, 2016, 16 (06) :530-535
[19]   Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity [J].
Kubota, Masaru ;
Nakata, Rieko ;
Adachi, Souichi ;
Watanabe, Ken-Ichiro ;
Heike, Toshio ;
Takeshita, Yasufumi ;
Shima, Midori .
LEUKEMIA & LYMPHOMA, 2014, 55 (07) :1591-1595
[20]   A Randomized, Controlled, Double-Blind, Pilot Study of Milk Thistle for the Treatment of Hepatotoxicity in Childhood Acute Lymphoblastic Leukemia (ALL) [J].
Ladas, Elena J. ;
Kroll, David J. ;
Oberlies, Nicholas H. ;
Cheng, Bin ;
Nclao, Deborah H. ;
Rheingold, Susan R. ;
Kelly, Kara M. .
CANCER, 2010, 116 (02) :506-513
1234