Identification of asthma clusters in two independent Korean adult asthma cohorts

被引：112

作者：

Kim, Tae-Bum ^{[1
]}

Jang, An-Soo ^{[2
]}

Kwon, Hyouk-Soo ^{[1
]}

Park, Jong-Sook ^{[2
]}

Chang, Yoon-Seok ^{[3
]}

Cho, Sang-Heon ^{[3
]}

Choi, Byoung Whui ^{[4
]}

Park, Jung-Won ^{[5
]}

Nam, Dong-Ho ^{[6
]}

Yoon, Ho-Joo ^{[7
]}

Cho, Young-Joo ^{[8
]}

Moon, Hee-Bom ^{[1
]}

Cho, You Sook ^{[1
]}

Park, Choon-Sik ^{[2
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Internal Med, Div Allergy & Clin Immunol,Asthma Ctr, Seoul, South Korea

[2] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Genome Res Ctr Allergy & Resp Dis, Puchon, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea

[4] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul 156756, South Korea

[5] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[6] Ajou Univ, Coll Med, Dept Internal Med, Suwon 441749, South Korea

[7] Hanyang Univ, Coll Med, Dept Internal Med, Seoul 133791, South Korea

[8] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea

来源：

EUROPEAN RESPIRATORY JOURNAL | 2013年 / 41卷 / 06期

关键词：

Asthma; classification; cluster analysis; phenotype; RESEARCH-PROGRAM; PHENOTYPES; MANAGEMENT; MECHANISMS; CHALLENGE; DISEASE; LUNG;

D O I：

10.1183/09031936.00100811

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Asthma is a heterogeneous airway disease with various clinical phenotypes. It is crucial to clearly identify clinical phenotypes to achieve better asthma management. We used cluster analysis to classify the clinical groups of 724 asthmatic patients from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA), and in 1843 subjects from another independent Korean asthma cohort of Soonchunhyang University Asthma Genome Research Centre (SCH) (Bucheon, Republic of Korea). Hierarchical cluster analysis was performed by Ward's method, followed by it-means cluster analysis. Cluster analysis of the COREA cohort indicated four asthma subtypes: 1) smoking asthma; 2) severe obstructive asthma; 3) early-onset atopic asthma; and 4) late-onset mild asthma. An independent cluster analysis of the SCH cohort also indicated four clusters that were similar to the COREA clusters. Our results indicate that adult Korean asthma patients can be classified into four distinct clusters.

引用

页码：1308 / 1314

页数：7

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