Microtubule-associated protein 1B is implicated in stem cell commitment and nervous system regeneration in planarians

被引：1
|
作者：
Gambino, Gaetana [1 ]
Rossi, Leonardo [1 ]
Iacopetti, Paola [1 ]
Ghezzani, Claudio [1 ]
Guidi, Patrizia [1 ]
Linsalata, Stefania [2 ]
Ippolito, Chiara [1 ]
Salvetti, Alessandra [1 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy
[2] Azienda Osped Univ Pisana, Med Phys Unit, Pisa, Italy
来源：
PLOS ONE | 2022年 / 17卷 / 12期
关键词：
EYE REGENERATION; GENE; ORGANIZATION; PLASTICITY; PATHWAY;
D O I：
10.1371/journal.pone.0278966
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Microtubule-associated 1B (MAP1B) proteins are expressed at the nervous system level where they control cytoskeleton activity and regulate neurotransmitter release. Here, we report about the identification of a planarian MAP1B factor (DjMap1B) that is enriched in cephalic ganglia and longitudinal nerve cords but not in neoblasts, the plentiful population of adult stem cells present in planarians, thanks to which these animals can continuously cell turnover and regenerate any lost body parts. DjMap1B knockdown induces morphological anomalies in the nervous system and affects neoblast commitment. Our data put forward a correlation between a MAP1B factor and stem cells and suggest a function of the nervous system in non-cell autonomous control of planarian stem cells.
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页数：17
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