Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)

被引：12

作者：

Specovius, Svenja ^{[1
,2
,3
,4
,5
,6
]}

Zimmermann, Hanna G. ^{[1
,2
,3
,4
,5
,6
]}

Oertel, Frederike Cosima ^{[1
,2
,3
,4
,5
,6
]}

Chien, Claudia ^{[1
,2
,3
,4
,5
,6
]}

Bereuter, Charlotte ^{[1
,2
,3
,4
,5
,6
]}

Cook, Lawrence J. ^{[7
]}

Lana Peixoto, Marco Aurelio ^{[8
]}

Fontenelle, Mariana Andrade ^{[8
]}

Kim, Ho Jin ^{[9
]}

Hyun, Jae-Won ^{[9
]}

Jung, Su-Kyung ^{[10
]}

Palace, Jacqueline ^{[11
]}

Roca-Fernandez, Adriana ^{[12
]}

Diaz, Alejandro Rubio ^{[11
]}

Leite, Maria Isabel ^{[11
]}

Sharma, Srilakshmi M. ^{[13
]}

Ashtari, Fereshte ^{[14
]}

Kafieh, Rahele ^{[15
]}

Dehghani, Alireza ^{[16
]}

Pourazizi, Mohsen ^{[16
]}

Pandit, Lekha ^{[17
]}

Dcunha, Anitha ^{[17
]}

Aktas, Orhan ^{[18
]}

Ringelstein, Marius ^{[18
,19
]}

Albrecht, Philipp ^{[18
]}

May, Eugene ^{[20
]}

Tongco, Caryl ^{[20
]}

Leocani, Letizia ^{[21
,22
,23
]}

Pisa, Marco ^{[21
,22
,23
]}

Radaelli, Marta ^{[21
,22
,23
]}

Martinez-Lapiscina, Elena H. ^{[24
]}

Stiebel-Kalish, Hadas ^{[25
,26
]}

Hellmann, Mark ^{[25
]}

Lotan, Itay ^{[25
]}

Siritho, Sasitorn ^{[27
,28
]}

de Seze, Jerome ^{[29
]}

Senger, Thomas ^{[29
]}

Havla, Joachim ^{[30
]}

Marignier, Romain ^{[31
]}

Tilikete, Caroline ^{[32
]}

Cobo Calvo, Alvaro ^{[31
]}

Bichuetti, Denis Bernardi ^{[33
]}

Tavares, Ivan Maynart ^{[34
]}

Asgari, Nasrin ^{[35
,36
,37
]}

Soelberg, Kerstin ^{[35
,36
,37
]}

Altintas, Ayse ^{[38
,39
]}

Yildirim, Rengin ^{[40
]}

Tanriverdi, Uygur ^{[41
]}

Jacob, Anu ^{[42
]}

Huda, Saif ^{[42
]}

机构：

[1] Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany

[2] Charite Univ Med Berlin, Berlin, Germany

[3] Free Univ Berlin, Berlin, Germany

[4] Humboldt Univ, Berlin, Germany

[5] Berlin Inst Hlth, Berlin, Germany

[6] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[7] Univ Utah, Dept Pediat, Salt Lake City, UT USA

[8] Univ Minas Gerais, Med Sch, CIEM MS Res Ctr, Belo Horizonte, MG, Brazil

[9] Natl Canc Ctr, Dept Neurol, Goyang, South Korea

[10] Natl Canc Ctr, Dept Ophthalmol, Goyang, South Korea

[11] Oxford Univ Hosp, Dept Neurol, Natl Hlth Serv Trust, Oxford, England

[12] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[13] Oxford Univ Hosp, Dept Ophthalmol, Natl Hlth Serv Trust, Oxford, England

[14] Isfahan Univ Med Sci, Kashani MS Ctr, Esfahan, Iran

[15] Isfahan Univ Med Sci, Sch Adv Technol Med, Esfahan, Iran

[16] Isfahan Univ Med Sci, Isfahan Eye Res Ctr, Dept Ophthalmol, Esfahan, Iran

[17] Nitte Univ, KS Hegde Med Acad, Dept Neurol, Mangalore, India

[18] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Neurol, Dusseldorf, Germany

[19] Heinrich Heine Univ Dusseldorf, Ctr Neurol & Neuropsychiat, Department Neurol, LVR Klinikum, Dusseldorf, Germany

[20] Swedish Neurosci Inst Neuroophthalmol, Seattle, WA USA

[21] Hosp San Raffaele, Neurol Dept, Sci Inst, Milan, Italy

[22] Hosp San Raffaele, Inst Expt Neurol INSPE, Sci Inst, Milan, Italy

[23] Univ Vita Salute San Raffaele, Milan, Italy

[24] Biomed August Pi Sunyer IDIBAPS, Hosp Clin Barcelona, Inst Invest, Barcelona, Spain

[25] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[26] Rabin Med Ctr, Neuroophthalmol Div, Dept Ophthalmol, Petah Tiqwa, Israel

[27] Siriraj Hosp, Dept Med, Div Neurol, Bangkok, Thailand

[28] Bumrungrad Int Hosp, Bangkok, Thailand

[29] Univ Hosp Strasbourg, Neurol Serv, Strasbourg, France

[30] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Clin Neuroimmunol, Munich, Germany

[31] Hosp Civils Lyon, Pierre Wertheimer Neurol Hosp, Neurol Multiple Sclerosis Myelin Disorders & Neur, Lyon, France

[32] Hosp Civils Lyon, Dept Neuroophthalmol, Lyon, France

[33] Univ Fed Sao Paulo, Dept Neurol & Neurocirurg, Escola Paulista Med, Sao Paulo, Brazil

[34] Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, Brazil

[35] Slagelse Hosp, Dept Neurol, Slagelse, Denmark

[36] Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark

[37] Univ Southern Denmark, Inst Mol Med, Odense, Denmark

[38] Koc Univ, Neurol Dept, Sch Med, Istanbul, Turkey

[39] Istanbul Univ, Cerrahpasa Sch Med, Istanbul, Turkey

[40] Istanbul Univ, Cerrahpasa Med Fac, Dept Ophthalmol, Istanbul, Turkey

[41] Istanbul Univ, Cerrahpasa Med Sch, Neurol Dept Istanbul, Istanbul, Turkey

[42] Walton Ctr NHS Fdn Trust, Dept Neurol, Liverpool, Merseyside, England

[43] NYU, Sch Med, Dept Neurol, Multiple Sclerosis Comprehens Care Ctr, New York, NY USA

[44] Univ Michigan, Sch Med, Dept Neurol, Ann Arbor, MI USA

[45] Hosp Clin Maracaibo, Dept Neurol, Maracaibo, Venezuela

[46] Univ Calif Los Angeles, Med Ctr, Dept Med, Los Angeles Biomed Res Inst Harbor, Torrance, CA 90509 USA

[47] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[48] Kellogg Eye Ctr, Dept Ophthalmol, Ann Arbor, MI USA

[49] Kellogg Eye Ctr, Dept Visual Sci, Ann Arbor, MI USA

[50] Univ Michigan, Sch Med, Dept Internal Med, Div Metab Endocrine & Diabet, Ann Arbor, MI USA

来源：

BMJ OPEN | 2020年 / 10卷 / 10期

关键词：

neuro-ophthalmology; neurology; medical retina; radiology & imaging; MYELIN-OLIGODENDROCYTE-GLYCOPROTEIN; MULTIPLE-SCLEROSIS; LAYER SEGMENTATION; CLINICAL-FEATURES; NEURITIS; MOG; ABNORMALITIES; DISEASE; ANTIBODIES; OCT;

D O I：

10.1136/bmjopen-2019-035397

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. Participants The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. Findings to date The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. Future plans We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.

引用

页数：9

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