Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

被引：3

作者：

Shao, Taiming ^{[1
,2
]}

Li, Xiaobao ^{[1
]}

Qi, Cuicui ^{[1
]}

Chen, Guangying ^{[1
]}

Song, Xiaoping ^{[1
]}

Han, Changri ^{[1
,2
]}

Zheng, Caijuan ^{[1
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571127, Hainan, Peoples R China

[2] Hainan Inst Sci & Technol, Sch Chem & Mat Engn, Key Lab Med & Edible Plants Resources Hainan Prov, Haikou 571126, Hainan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Ficus auriculata; chemical constituent; isoflavone; anti osteoporosis activity; LEAVES;

D O I：

10.6023/cjoc201709008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five isoflavonoids were isolated from the roots of the Ficus auriculata by means of silica gel column, HPLC and other chromatography methods. By using spectroscopic techniques including NMR, IR and UV, their structures were identified as 5,7,4'-trihydroxy-8-(1-hydroxy-2,3-epoxy-3-methylbutyl) isoflavone (1), 5,7,4'-trihydroxy-3'-(2,6,7-trihydroxy-3-methylene7-methyloctyl) isoflavone (2), 5,7,4'-trihydroxy-6-[(S)-2,3-dihydroxy-3-methylbutyl] isoflavone (3), 5,7,4'-trihydroxy-6-prenylisoflavone (4), and 5,7,4'-trihydroxy-3'-prenylisoflavone (5). Compounds 1 and 2 were new isoflavonoids. All compounds were evaluated for their anti osteoporosis activities in vitro. Compounds 4 and 5 showed moderate proliferation function of primary osteoblasts in 100 mu mol/L.

引用

页码：710 / 714

页数：5

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