Cellular imaging in drug discovery

被引：256

作者：

Lang, P ^{[1
]}

Yeow, K ^{[1
]}

Nichols, A ^{[1
]}

Scheer, A ^{[1
]}

机构：

[1] Serono Pharmaceut Res Inst, Dept Mol Screening & Cellular Pharmacol, CH-1228 Plan Les Ouates, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrd2008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Traditional screening paradigms often focus on single targets. To facilitate drug discovery in the more complex physiological environment of a cell or organism, powerful cellular imaging systems have been developed. The emergence of these detection technologies allows the quantitative analysis of cellular events and visualization of relevant cellular phenotypes. Cellular imaging facilitates the integration of complex biology into the screening process, and addresses both high-content and high-throughput needs. This review describes how cellular imaging technologies contribute to the drug discovery process.

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页码：343 / 356

页数：14

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