Irradiated normal brain promotes invasion of glioblastoma through vascular endothelial growth and stromal cell-derived factor 1

被引：10

作者：

Zhou, Wei ^{[1
]}

Xu, Yangyang ^{[2
,3
]}

Gao, Ge ^{[4
]}

Jiang, Zheng ^{[2
,3
]}

Li, Xingang ^{[2
,3
]}

机构：

[1] Shandong Univ, Dept Radiotherapy, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Dept Neurosurg, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Brain Sci Res Inst, Jinan 250012, Shandong, Peoples R China

[4] Shandong Acad Med Sci, Affiliated Hosp, Jinan, Shandong, Peoples R China

来源：

NEUROREPORT | 2013年 / 24卷 / 13期

基金：

中国国家自然科学基金;

关键词：

CXCR4; glioma; radiotherapy; GLIOMA-CELLS; INVASIVENESS; RADIATION; VASCULOGENESIS; RADIOTHERAPY; INDUCTION; CXCL12;

D O I：

10.1097/WNR.0b013e32836459ac

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The significance of irradiated normal brain volume in glioma recurrence is usually ignored by radiotherapists. The whole-brain irradiation (WBI) of 15 Gy in three fractions was delivered to C57BL/6 mice before implantation of GL261 glioma cells. The changes in vascular endothelial growth (VEGF) and stromal cell-derived factor 1 (SDF-1) after WBI were evaluated by real-time RT-PCR and immunohistochemistry. Cell invasion assays were performed to study the effects of VEGF and SDF-1. The levels of VEGF and SDF-1 in normal brain tissues increased after 15 Gy WBI. The WBI before tumor implantation significantly increased the invasive ability of GL261 cells. VEGF and SDF-1 could promote invasion of GL261 cells even after high-dose irradiation. The combination of irradiation and inhibitors such as AMD3100 may prevent irradiation-stimulated dissemination of glioma cells.

引用

页码：730 / 734

页数：5

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