Effect of oral vanadyl sulfate treatment on serum enzymes and lipids of streptozotocin-diabetic young rats

被引：10
作者：
Pepato, MT
Magnani, MRT
Kettelhut, IC
Brunetti, IL
机构：
[1] UNESP, Fac Pharmaceut Sci Araraquara, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Biochem, BR-05508 Sao Paulo, Brazil
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1999年 / 198卷 / 1-2期
关键词：
vanadyl sulfate; hyperglycemia; diabetes mellitus; insulin; serum enzymes;
D O I：
10.1023/A:1006917007148
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this work we investigate the possible toxicity of vanadyl sulfate (VOSO4), a compound capable of reducing hyperglycemia, on the following serum enzymes of diabetic young rats: alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LD) and creatine kinase (CK), as well as its effects on serum lipids. We find that at a concentration of 1 mg/mL VOSO4 has no toxic effect on the liver and muscles of diabetics young rats. These findings suggest that VOSO4 may be an alternative to insulin in the near future, due to its low cost, low toxicity and ready availability.
引用
收藏
页码：157 / 161
页数：5
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