Phyllaciduloids A-D: Four new cleistanthane diterpenoids from Phyllanthus acidus (L.) Skeels

被引：17

作者：

Zheng, Xiao-Hong ^{[1
,2
]}

Yang, Jing ^{[1
,3
]}

Lv, Jun-Jiang ^{[4
]}

Zhu, Hong-Tao ^{[1
,3
]}

Wang, Dong ^{[1
,3
]}

Xu, Min ^{[5
]}

Yang, Chong-Ren ^{[1
]}

Zhang, Ying-Jun ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, Yuman Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China

[4] Chongqing Univ, Chem & Chem Engn Coll, Chongqing 400030, Peoples R China

[5] Kunming Univ Technol & Sci, Fac Life Sci & Technol, Kunming 650504, Yunnan, Peoples R China

来源：

FITOTERAPIA | 2018年 / 125卷

基金：

中国国家自然科学基金;

关键词：

Phyllanthus acidus; Phyllanthaceae; Cleistanthane diterpenoids; Phyllaciduloids A-D; EXTRACTS; SESQUITERPENOIDS; EUPHORBIACEAE; EMBLICA; PLANTS;

D O I：

10.1016/j.fitote.2017.12.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new cleistanthane diterpenoids, phyllaciduloids A-D (1-4), were isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. Phyllaciduloids B-D (2-4) present in their structures with ether bond between C-7 and C-16, which were rarely reported. All the isolates were evaluated for their cytotoxic activities against five human cancer cell lines.

引用

页码：89 / 93

页数：5

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