Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

被引：10
作者：
Zheng, Zhen [1 ]
Zheng, Peng [2 ]
Zou, Xiaobing [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Pediat, Guangzhou 510630, Guangdong, Peoples R China
[2] South China Agr Univ, Coll Hort, Guangzhou 510642, Guangdong, Peoples R China
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2021年 / 51卷 / 08期
基金：
美国国家科学基金会;
关键词：
Autism spectrum disorder; Blood; S100B; Meta-analysis; NEURON-SPECIFIC ENOLASE; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; ACIDIC PROTEIN; SERUM-LEVELS; CHILDREN; BIOMARKERS; MARKER; RATS;
D O I：
10.1007/s10803-020-04710-1
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41-1.53;p < 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.
引用
收藏
页码：2569 / 2577
页数：9
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