Novel 7-hydroxycoumarin based fluorescent labels

被引：40
作者：
Adamczyk, M
Cornwell, M
Huff, J
Rege, S
Rao, TVS
机构：
[1] Abbott Laboratories, Diagnostics Division, D9NM/AP20, Abbott Park, IL 60064
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 15期
关键词：
D O I：
10.1016/S0960-894X(97)00345-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new 7-hydroxy-8-(N-alkylaminomethyl)coumarin labels (6a-e) were prepared from 4-(4-carboxybutyl)-7-hydroxycoumarin (4) in 28-48% yield. Compared to 4-methylumbelliferone (4-MU, 1), the new fluorescent labels exhibited higher emission intensity over a broader pH range. Extinction coefficients, quantum yields and pKa values are also reported for these labels. (C) 1997 Elsevier Science Ltd.
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页码：1985 / 1988
页数：4
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