Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

被引：8
|
作者：
Benson, Neil [1 ]
van der Graaf, Piet H. [2 ]
Peletier, Lambertus A. [3 ]
机构：
[1] Xenologiq Ltd, Unit 7, Canterbury CT4 6HD, Kent, England
[2] Pfizer Ltd, Pharmacometr, Global Clin Pharmacol, Sandwich CT13 9NJ, Kent, England
[3] Leiden Univ, Math Inst, NL-2300 RA Leiden, Netherlands
来源：
JOURNAL OF MATHEMATICAL BIOLOGY | 2013年 / 66卷 / 4-5期
关键词：
Receptors; Tyrosine Kinase; Signal transduction; Systems biology; Systems pharmacology; Singular perturbation; MEDIATED DRUG DISPOSITION; DYNAMICS; MODEL; PKPD;
D O I：
10.1007/s00285-012-0620-z
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Receptor tyrosine kinases are high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. They straddle the cell wall and play an important role in cross-membrane signalling. We present a two-component systems pharmacology model based on the local physiology and identify characteristic features of its dynamics. We thus present a transparent tool for studying the effects of drug intervention and ways of administration on cross-membrane signalling through these receptors.
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页码：719 / 742
页数：24
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