MicroRNA in non-melanoma skin cancer

被引:30
作者
Sand, Michael [1 ]
Sand, Daniel [2 ]
Altmeyer, Peter [1 ]
Bechara, Falk G. [1 ]
机构
[1] Ruhr Univ Bochum, Dept Dermatol Venereol & Allergol, D-44791 Bochum, Germany
[2] Univ Calif Los Angeles, Dept Med, Olive View UCLA Med Ctr, Los Angeles, CA 90024 USA
关键词
microRNA; non-melanoma skin cancer; epithelial skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; SQUAMOUS-CELL CARCINOMA; EXPRESSION; ADENOCARCINOMA; METASTASIS; APOPTOSIS; ONCOGENE; SURVIVAL; PATHWAY; DROSHA;
D O I
10.3233/CBM-2012-0274
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MicroRNAs (miRNAs) are a fairly novel class of 17- to 23-nucleotide (nt), short, non-coding RNA molecules that have revolutionized our understanding of gene regulation and opened new possibilities in the future of gene therapy. Here, we review the potential role of miRNAs in non-melanoma skin cancer (NMSC) and summarize the current studies available in this new aspect of NMSC research.
引用
收藏
页码:253 / 257
页数:5
相关论文
共 38 条
[11]   Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype [J].
Heffelfinger, Christopher ;
Ouyang, Zhengqing ;
Engberg, Anna ;
Leffell, David J. ;
Hanlon, Allison M. ;
Gordon, Patricia B. ;
Zheng, Wei ;
Zhao, Hongyu ;
Snyder, Michael P. ;
Bale, Allen E. .
G3-GENES GENOMES GENETICS, 2012, 2 (02) :279-286
[12]   Multiple metastases of carcinoma basocellulare into spinal column [J].
Jarus-Dziedzic, K ;
Zub, W ;
Dziedzic, D ;
Jelen, M ;
Krotochwil, J ;
Mierzejewski, M .
JOURNAL OF NEURO-ONCOLOGY, 2000, 48 (01) :57-62
[13]   MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells [J].
Jiang, Lili ;
Huang, Qin ;
Chang, Jihong ;
Wang, Enhua ;
Qiu, Xueshan .
EXPERIMENTAL LUNG RESEARCH, 2011, 37 (07) :387-398
[14]   Trends in incidence of nonmelanoma skin cancers in Alberta, Canada, 1988-2007 [J].
Jung, G. W. ;
Metelitsa, A. I. ;
Dover, D. C. ;
Salopek, T. G. .
BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (01) :146-154
[15]   Silencing of microRNAs in vivo with 'antagomirs' [J].
Krützfeldt, J ;
Rajewsky, N ;
Braich, R ;
Rajeev, KG ;
Tuschl, T ;
Manoharan, M ;
Stoffel, M .
NATURE, 2005, 438 (7068) :685-689
[16]   BIOLOGY OF CUTANEOUS SQUAMOUS-CELL CARCINOMA [J].
KWA, RE ;
CAMPANA, K ;
MOY, RL .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1992, 26 (01) :1-26
[17]   Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study [J].
Lajer, C. B. ;
Nielsen, F. C. ;
Friis-Hansen, L. ;
Norrild, B. ;
Borup, R. ;
Garnaes, E. ;
Rossing, M. ;
Specht, L. ;
Therkildsen, M. H. ;
Nauntofte, B. ;
Dabelsteen, S. ;
von Buchwald, C. .
BRITISH JOURNAL OF CANCER, 2011, 104 (05) :830-840
[18]   The role of PACT in the RNA silencing pathway [J].
Lee, Y ;
Hur, I ;
Park, SY ;
Kim, YK ;
Suh, MR ;
Kim, VN .
EMBO JOURNAL, 2006, 25 (03) :522-532
[19]   MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor [J].
Li, Jinsong ;
Huang, Hongzhang ;
Sun, Lijuan ;
Yang, Mei ;
Pan, Chaobin ;
Chen, Weiliang ;
Wu, Donghui ;
Lin, Zhaoyu ;
Zeng, Chunxian ;
Yao, Yandan ;
Zhang, Peter ;
Song, Erwei .
CLINICAL CANCER RESEARCH, 2009, 15 (12) :3998-4008
[20]   Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma [J].
Li, Yang ;
Tan, Weiqi ;
Neo, Thomas W. L. ;
Aung, Myat O. ;
Wasser, Shanthi ;
Lim, Seng G. ;
Tan, Theresa M. C. .
CANCER SCIENCE, 2009, 100 (07) :1234-1242