Organocatalytic three-component reactions of pyruvate, aldehyde and aniline by hydrogen-bonding catalysts

被引：54

作者：

Li, Xin ^{[1
]}

Deng, Hui ^{[2
,3
]}

Luo, Sanzhong ^{[1
]}

Cheng, Jin-Pei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, BNLMS, Ctr Chem Biol, Inst Chem, Beijing 100190, Peoples R China

[2] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China

[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 25期

关键词：

hydrogen bonds; multicomponent reactions; chirality; phosphoric acids; thioureas; asymetric catalysis;

D O I：

10.1002/ejoc.200800491

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrogen-bonding catalysts have been found to catalyze one-pot three-component reactions of pyruvate, anilines and aldehydes to afford versatile 3-amino-1, 5-dihydro-2H-pyrrol2-ones in high yields. Both, thioureas and phosphoric acids are viable catalysts for these reactions and have comparable activity. The corresponding chiral thioureas and phosphoric acids have also been used in these three-component reactions to give pyrrol-2-ones in high yields and with moderate enantioselectivities. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：4350 / 4356

页数：7

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