Levetiracetam for busulfan-induced seizure prophylaxis in children undergoing hematopoietic stem cell transplantation

被引：31
作者：
Soni, Sandeep [1 ]
Skeens, Micah [1 ]
Termuhlen, Amanda M. [1 ]
Bajwa, Rajinder P. S. [1 ]
Gross, Thomas G. [1 ]
Pai, Vinita [1 ,2 ]
机构：
[1] Nationwide Childrens Hosp, Div Pediat Hematol Oncol & BMT, Columbus, OH 43205 USA
[2] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA
来源：
PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 04期
关键词：
BMT; busulfan; levetiracetam; seizures; HIGH-DOSE BUSULFAN; ACUTE-LEUKEMIA PATIENTS; MARROW TRANSPLANTATION; DRUG-INTERACTIONS; PHARMACOKINETICS; CYCLOPHOSPHAMIDE; LORAZEPAM;
D O I：
10.1002/pbc.24126
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Anti-seizure prophylaxis is routinely utilized during busulfan administration for HSCT. We evaluated the feasibility and efficacy of levetiracetam in children undergoing HSCT. A total of 28 children and young adults received levetiracetam during HSCT and the outcomes and costs were compared to a historical, but similar cohort of 25 patients who had received fosphenytoin. Levetiracetam was well tolerated and was efficacious in preventing seizures. Cost of drug, administration, and monitoring were also similar among the two groups. Due to non-induction of the hepatic cytochrome P450 enzymes, levetiracetam may lead to better dose assurance of busulfan in targeted dose regimens for HSCT. Pediatr Blood Cancer 2012;59:762764. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：762 / 764
页数：3
相关论文
共 50 条
  • [41] Simultaneous determination of busulfan, fludarabine, phenytoin, and posaconazole in plasma from patients undergoing hematopoietic stem cell transplantation
    Jiang, Xijuan
    Liu, Jia
    Feng, Xuan
    Ding, Weijing
    Han, Yu
    Qin, Yabin
    Zhao, Yile
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 257
  • [42] Model-Informed Precision Dosing of Intravenous Busulfan in Thai Pediatrics Undergoing Hematopoietic Stem Cell Transplantation
    Puangpetch, Apichaya
    Thomas, Fabienne
    Anurathapan, Usanarat
    Pakakasama, Samart
    Hongeng, Suradej
    Rachanakul, Jiratha
    Prommas, Santirhat
    Nuntharadthanaphong, Nutthan
    Chatelut, Etienne
    Sukasem, Chonlaphat
    Le Louedec, Felicien
    THERAPEUTIC DRUG MONITORING, 2024, 46 (06) : 778 - 785
  • [43] Role of pharmacogenetics in busulfan/cyclophosphamide conditioning therapy prior to hematopoietic stem cell transplantation
    Hassan, Moustapha
    Andersson, Borje S.
    PHARMACOGENOMICS, 2013, 14 (01) : 75 - 87
  • [44] Prospective pharmacokinetic study of intravenous busulfan in hematopoietic stem cell transplantation in 25 children
    Okamoto, Yasuhiro
    Nagatoshi, Yoshihisa
    Kosaka, Yoshiyuki
    Kikuchi, Akira
    Kato, Shunichi
    Kigasawa, Hisato
    Horikoshi, Yasuo
    Oda, Megumi
    Kaneda, Makoto
    Mori, Tetsuya
    Mugishima, Hideo
    Tsuchida, Masahiro
    Taniguchi, Shuichi
    Kawano, Yoshifumi
    PEDIATRIC TRANSPLANTATION, 2014, 18 (03) : 294 - 301
  • [45] Risk of Seizures in Children Receiving Busulphan-Containing Regimens for Stem Cell Transplantation
    Caselli, Desiree
    Rosati, Anna
    Faraci, Maura
    Podda, Marta
    Ripaldi, Mimmo
    Longoni, Daniela
    Cesaro, Simone
    Lo Nigro, Luca
    Paolicchi, Olivia
    Maximova, Natasha
    Menconi, Maria Cristina
    Ziino, Ottavio
    Cicalese, Maria Pia
    Santarone, Stella
    Nesi, Francesca
    Arico, Maurizio
    Locatelli, Franco
    Prete, Arcangelo
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (02) : 282 - 285
  • [46] Impact of GSTA1 Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation
    Michaud, Veronique
    Tran, My
    Pronovost, Benoit
    Bouchard, Philippe
    Bilodeau, Sarah
    Alain, Karine
    Vadnais, Barbara
    Franco, Martin
    Belanger, Francois
    Turgeon, Jacques
    PHARMACEUTICS, 2019, 11 (09)
  • [47] Evaluation of Limited Sampling Methods for Oral Busulfan Pharmacokinetic Monitoring in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation
    Bouchard, Philippe
    Bilodeau, Sarah
    Alain, Karine
    Vadnais, Barbara
    Franco, Martin
    Turgeon, Jacques
    Michaud, Veronique
    THERAPEUTIC DRUG MONITORING, 2016, 38 (03) : 414 - 418
  • [48] Population pharmacokinetic study of a test dose oral busulfan in Japanese adult patients undergoing hematopoietic stem cell transplantation
    Takamatsu, Yasushi
    Sasaki, Noriaki
    Ogata, Kentaro
    Yukawa, Eiji
    Jimi, Shiro
    Hara, Shuuji
    Tamura, Kazuo
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2010, 65 (06) : 1203 - 1207
  • [49] Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation
    Choi, Boyoon
    Kim, Myeong Gyu
    Han, Nayoung
    Kim, Therasa
    Ji, Eunhee
    Park, Seonyang
    Kim, In-Wha
    Oh, Jung Mi
    PHARMACOGENOMICS, 2015, 16 (14) : 1585 - 1594
  • [50] Comparison of levetiracetam versus phenytoin/fosphenytoin for busulfan seizure prophylaxis at a pediatric institution
    Hughes, Kaitlynn
    Garrity, Lisa
    Nelson, Adam S.
    Lane, Adam
    Teusink-Cross, Ashley
    PEDIATRIC TRANSPLANTATION, 2021, 25 (04)
12345