Expression of Stanniocalcin 1 as a Potential Biomarker of Gastric Cancer

被引：26

作者：

Arigami, Takaaki ^{[1
,2
]}

Uenosono, Yoshikazu

Ishigami, Sumiya ^{[2
]}

Hagihara, Takahiko ^{[2
]}

Haraguchi, Naoto ^{[2
]}

Matsushita, Daisuke ^{[2
]}

Yanagita, Shigehiro ^{[2
]}

Nakajo, Akihiro ^{[2
]}

Okumura, Hiroshi ^{[2
]}

Hokita, Shuichi ^{[3
]}

Natsugoe, Shoji ^{[2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Course Adv Therapeut, Dept Digest Surg,Field Oncol, Kagoshima 8908520, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Field Oncol, Dept Digest Surg Breast & Thyroid Surg, Kagoshima 8908520, Japan

[3] Jiaikai Imamura Hosp, Dept Surg, Kagoshima, Japan

来源：

ONCOLOGY | 2012年 / 83卷 / 03期

关键词：

Blood marker; Gastric cancer; Stanniocalcin; 1; Reverse transcription-polymerase chain reaction; Tumor progression; CIRCULATING TUMOR-CELLS; LYMPH-NODE MICROMETASTASIS; CLINICAL-SIGNIFICANCE; MARKER; CHEMOTHERAPY; PROGRESSION; SURVIVAL; ANTIBODY; BLOOD; CDNA;

D O I：

10.1159/000341390

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness. Methods: Blood specimens from 93 patients with gastric cancer and 21 normal healthy volunteers were assessed by quantitative reverse transcription-polymerase chain reaction for STC 1 mRNA expression. Results: The relative numbers of STC 1 mRNA copies were significantly higher in gastric cancer cell lines and in blood specimens from patients with gastric cancer than in blood specimens from healthy volunteers (p = 0.0001 and p = 0.003, respectively). The sensitivity and specificity of STC 1 mRNA expression for discriminating patients with gastric cancer from healthy volunteers were 69.9 and 71.4%, respectively. Furthermore, the sensitivity for STC 1 mRNA was higher than that for serum carcinoembryonic antigen and carbohydrate antigen 19-9. The presence of STC 1 expression was significantly correlated with depth of tumor invasion and tumor stage (p = 0.032 and p = 0.013, respectively). Conclusion: Our data strongly suggest that STC 1 is a potentially useful blood marker for predicting biological tumor aggressiveness in patients with gastric cancer. Copyright (c) 2012 S. Karger AG, Basel

引用

页码：158 / 164

页数：7

共 30 条

[1] Evaluation of sentinel node concept in gastric cancer based on lymph node micrometastasis determined by reverse transcription-polymerase chain reaction [J].

Arigami, T ;

Natsugoe, S ;

Uenosono, YA ;

Mataki, Y ;

Ehi, K ;

Higashi, H ;

Arima, H ;

Yanagida, S ;

Ishigami, S ;

Hokita, S ;

Aikou, T .

ANNALS OF SURGERY, 2006, 243 (03) :341-347

[2] Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer [J].

Arigami, T ;

Natsugoe, S ;

Uenosono, Y ;

Arima, H ;

Mataki, Y ;

Ehi, K ;

Yanagida, S ;

Ishigami, S ;

Hokita, S ;

Aikou, T .

BRITISH JOURNAL OF CANCER, 2005, 93 (06) :688-693

[3]

Bang YJ, 2010, LANCET, V376, P1302

[4] Mammalian stanniocalcins and cancer [J].

Chang, ACM ;

Jellinek, DA ;

Reddel, RR .

[5] Identification of a second stanniocalcin cDNA in mouse and human: Stanniocalcin 2 [J].

Chang, ACM ;

Reddel, RR .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1998, 141 (1-2) :95-99

[6] A NOVEL HUMAN CDNA HIGHLY HOMOLOGOUS TO THE FISH HORMONE STANNIOCALCIN [J].

CHANG, ACM ;

JANOSI, J ;

HULSBEEK, M ;

DEJONG, D ;

JEFFREY, KJ ;

NOBLE, JR ;

REDDEL, RR .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 112 (02) :241-247

[7] Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer [J].

Cohen, Steven J. ;

Punt, Cornelis J. A. ;

Iannotti, Nicholas ;

Saidman, Bruce H. ;

Sabbath, Kert D. ;

Gabrail, Nashat Y. ;

Picus, Joel ;

Morse, Michael ;

Mitchell, Edith ;

Miller, M. Craig ;

Doyle, Gerald V. ;

Tissing, Henk ;

Terstappen, Leon W. M. M. ;

Meropol, Neal J. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (19) :3213-3221

[8] Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J].

Cristofanilli, M ;

Budd, GT ;

Ellis, MJ ;

Stopeck, A ;

Matera, J ;

Miller, MC ;

Reuben, JM ;

Doyle, GV ;

Allard, WJ ;

Terstappen, LWMM ;

Hayes, DF .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (08) :781-791

[9] The Diagnostic Value of Circulating Stanniocalcin-1 mRNA in Non-Small Cell Lung Cancer [J].

Du, Yu-Zhen ;

Gu, Xiao-Hua ;

Li, Li ;

Gao, Feng .

JOURNAL OF SURGICAL ONCOLOGY, 2011, 104 (07) :836-840

[10]

Edge S.B., 2010, AJCC cancer staging manual, V649

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