Progress and problems in the application of focused ultrasound for blood-brain barrier disruption

被引：193

作者：

Vykhodtseva, Natalia ^{[1
]}

McDannold, Nathan ^{[1
]}

Hynynen, Kullervo ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiol,Focused Ultrasound Lab, Boston, MA 02115 USA

[2] Univ Toronto & Imaging Res, Sunnybrook Hlth Sci Ctr, Dept Med Biophys, Toronto, ON M4N 3M5, Canada

来源：

ULTRASONICS | 2008年 / 48卷 / 04期

关键词：

ultrasound; blood-brain barrier; drug delivery; brain;

D O I：

10.1016/j.ultras.2008.04.004

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Advances in neuroscience have resulted in the development of new diagnostic and therapeutic agents for potential use in the central nervous system (CNS). However, the ability to deliver the majority of these agents to the brain is limited by the blood-brain barrier (BBB), a specialized structure of the blood vessel wall that hampers transport and diffusion from the blood to the brain. Many CNS disorders could be treated with drugs, enzymes, genes, or large-molecule biotechnological products such as recombinant proteins, if they could cross the BBB. This article reviews the problems of the BBB presence in treating the vast majority of CNS diseases and the efforts to circumvent the BBB through the design of new drugs and the development of more sophisticated delivery methods. Recent advances in the development of noninvasive, targeted drug delivery by MRI-guided ultrasound-induced BBB disruption are also summarized. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：279 / 296

页数：18

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