A Notch updated

被引：150
作者：
Tien, An-Chi [1 ]
Rajan, Akhila [2 ]
Bellen, Hugo J. [1 ,2 ,3 ,4 ]
机构：
[1] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Human Mol Genet, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
来源：
JOURNAL OF CELL BIOLOGY | 2009年 / 184卷 / 05期
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; GAMMA-SECRETASE CLEAVAGE; LIGAND-BINDING DOMAIN; E3 UBIQUITIN LIGASE; DROSOPHILA-MELANOGASTER; LUNATIC-FRINGE; CELL FATE; PROTEIN O-FUCOSYL-TRANSFERASE-1; O-FUCOSE; ENDOSOMAL TRAFFICKING;
D O I：
10.1083/jcb.200811141
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cell-cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation. These include complex sugar modifications in the extracellular domain as well as transit of Notch through defined cellular compartments, including specific endosomes.
引用
收藏
页码：621 / 629
页数：9
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