Vascular function in Type 2 diabetes mellitus and pre-diabetes: the case for intrinsic endotheliopathy

被引：48
|
作者：
Tooke, JE [1 ]
Goh, KL [1 ]
机构：
[1] Sch Postgrad Med & Hlth Sci, Dept Diabet & Vasc Med, Exeter EX2 5AX, Devon, England
来源：
DIABETIC MEDICINE | 1999年 / 16卷 / 09期
关键词：
endothelial dysfunction; fetal development; Type 2 diabetes mellitus;
D O I：
10.1046/j.1464-5491.1999.00099.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic angiopathy is a major cause of morbidity and mortality in Type 2 diabetes mellitus (DM). The pathogenesis of vascular complications in this condition appears to be complex, with distinct differences being observed between Type 1 and Type 2 DM. This review outlines the evidence for these differences and identifies endothelial dysfunction as an important associate and antecedent of Type 2DM, which predisposes to characteristic vascular complications and may also have implications for fetal development.
引用
收藏
页码：710 / 715
页数：6
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