The absolute configuration and total synthesis of korormicin

被引：23
作者：
Uehara, H
Oishi, T
Yoshikawa, K
Mochida, K
Hirama, M [1 ]
机构：
[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan
[2] Japan Sci & Technol Corp, CREST, Sendai, Miyagi 9808578, Japan
[3] Marine Biotechnol Inst, Shimizu Labs, Shimizu, Shizuoka 4240037, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期
关键词：
D O I：
10.1016/S0040-4039(99)01812-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The marine antibiotic korormicin, isolated from the culture filtrate of marine bacterial strain Pseudoalteromonas sp. F-420, specifically inhibits the growth of marine Gram-negative bacteria without affecting terrestrial species. The absolute configuration of korormicin was determined by the combination of a CD exciton chirality method and chemical degradation. Convergent total synthesis of korormicin has been also achieved. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：8641 / 8645
页数：5
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