hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis

被引：8
作者：
Geng, Peiliang [1 ]
Yao, Jie [1 ,2 ]
Zhu, Yunfeng [1 ,3 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Key Lab, Ctr Canc, Beijing 100853, Peoples R China
[2] PLA 161 Ctr Hosp, Dept Oncol, Wuhan 430010, Hubei, Peoples R China
[3] Beijing Jiao Tong Univ, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 04期
关键词：
Ser326Cys; hOGG1; Polymorphism; Susceptibility; Lung cancer; DNA-REPAIR ENZYME; GENETIC POLYMORPHISMS; HUMAN HOMOLOG; OGG1; GENE; RAT-LIVER; RISK; ASSOCIATION; CLONING; 8-HYDROXYGUANINE; CARCINOGENESIS;
D O I：
10.1007/s11033-014-3083-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Ser326Cys polymorphism in the human 8-oxogunaine glycosylase (hOGG1) gene with lung cancer susceptibility had been investigated by the approaches of PCR-RFLP, PCR-SSCP and ASA. Due to limited specimen and different approaches the conclusion was drawn toughly. To evaluate this correlation comprehensively, a meta-analysis was performed based on 30 case-control studies, including 10,327 cases and 12,148 controls. The random-effects model was used to estimate the odds ratios and 95 % confidence interval for various contrasts of this polymorphism. The combined results suggested that the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models. Similarly, in the stratified analyses by ethnicity and source of control, no risk was observed between all the genetic models and lung cancer risk. Our meta-analysis revealed that there was little correlation between the hOGG1 Ser326Cys polymorphism and the risk of lung cancer.
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收藏
页码：2299 / 2306
页数：8
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