A formal synthesis of (+)-didemniserinolipid B employing a Pd-mediated 6-endo selective alkynediol cycloisomerization

被引：24

作者：

Ramana, C. V. ^{[1
]}

Induvadana, Boddeti ^{[1
]}

机构：

[1] Natl Chem Lab, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 03期

关键词：

Didemniserinolipid; Bridged bicyclic ketal; Alkynol cycloisomerization; Zipper reaction; Yamaguchi oxirane alkyne coupling; NATURAL-PRODUCT; CATALYZED CYCLOISOMERIZATION; EFFICIENT METHOD; SUGAR ALKYNOLS; PALLADIUM; TRANSFORMATION; ACETALS; HYDROALKOXYLATION; CONFIGURATION; HETEROCYCLES;

D O I：

10.1016/j.tetlet.2008.10.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe a concise assembly of central 6,8-dioxabicyclo[3,2,1]octane core of didemniserino-lipid by employing a Pd-mediated alkynediol cycloisomerization and a formal total synthesis of didemniserinolipid (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：271 / 273

页数：3

共 43 条

[1]

Abrams SR, 1993, ORG SYNTH, V8, P146

[2] Transition-metal-catalyzed addition of heteroatom-hydrogen bonds to alkynes [J].