Nitric oxide mediates the antihypertensive and vascular relaxing effects of a soluble cocoa fiber product in spontaneously hypertensive rats

被引：3

作者：

Fernandez Vallinas, S. ^{[1
]}

Lopez Carreras, N. ^{[1
]}

Miguel, M. ^{[2
]}

Aleixandre, A. ^{[1
]}

机构：

[1] Univ Complutense, Fac Med, Dept Farmacol, E-28040 Madrid, Spain

[2] UAM, CSIC, CEI, Inst Invest Ciencias Alimentac, Madrid 28049, Spain

来源：

NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2013年 / 29卷

关键词：

Cocoa; Endothelium; Fiber; Hypertension; Nitric oxide; Spontaneously hypertensive rats;

D O I：

10.1016/j.niox.2012.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The involvement of endothelial-relaxing factors on the vascular and antihypertensive effects of a cocoa fiber product (CFP) obtained from cocoa husks was studied. We carried out in vitro experiments with aorta rings from untreated spontaneously hypertensive rats (SHR) and in vivo experiments with SHR. CFP did not relax the endothelium denuded aorta rings and N-W-nitro-L-arginine methyl ester (L-NAME) partially blocked the vascular relaxing and antihypertensive effects of CFP. Nevertheless, indomethacin did not modify these effects. Nitric oxide mediates therefore the antihypertensive and aorta relaxing effects of CFP in SHR. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1 / 3

页数：3

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