Treatment with cyclophosphamide in post-weaning mice causes prolonged suppression of neural stem cell proliferation in the hippocampal dentate gyrus

被引：1
作者：
Onaka, Yusuke [1 ]
Yamaguchi, Taro [1 ]
Yoneyama, Masanori [1 ]
机构：
[1] Setsunan Univ, Fac Pharmaceut Sci, Lab Pharmacol, Hirakata, Osaka 5730101, Japan
来源：
BRAIN RESEARCH | 2022年 / 1796卷
基金：
日本学术振兴会;
关键词：
Cyclophosphamide; Neurogenesis; Behavior; Late effect; Stress response; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDHOOD-CANCER; ADULT NEUROGENESIS; OXIDATIVE STRESS; SURVIVORS; RECEPTOR; BEHAVIOR; CRTH2; MODEL; RATS;
D O I：
10.1016/j.brainres.2022.148108
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of anticancer drugs used in childhood on brain function in adulthood are unclear. Here, we report the long-term changes in the proliferation of neuronal stem/progenitor cells (NPCs) in the hippocampal dentate gyrus after treatment with cyclophosphamide (CYP), which is often used as a therapeutic medicine in childhood cancer. A systemic injection of CYP into 3-week-old mice decreased 5-bromo-2 '-deoxyuridine (BrdU)-incorpo-rated cells in the hippocampal subgranular zone 2 and 55 days after the injection in a dose-dependent manner. Restraint stress induced increase in corticosterone level, which was enhanced by CYP at day 35 after injection. These findings suggest that CYP injection into post-weaning mice causes prolonged alteration in NPC prolifer-ation in the hippocampus and the stress response.
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页数：5
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