Preclosure of large-sized venous access sites in adults undergoing transcatheter structural interventions

Background Patients requiring congenital and structural heart interventions often require large-sized sheath insertion into femoral veins and arteries. Clinical outcome data on the use of suture-mediated devices for femoral venous access site closure are limited. Objective To assess the efficacy and safety of the Perclose (Abbott Vascular Devices, CA) suture-mediated device using the preclosure technique, in achieving haemostasis at femoral venous access site following large sheath insertion (8 Fr). Design and Setting Two hundred and forty-three consecutive patients underwent 310 access site closures with the Perclose device using the preclosure technique. There were 151 (62%) women, mean age 43 (+/- 16) years. 234/243 (96%) received heparin. Mean venous access site sheath diameter was 11.5 (+/- 3) Fr. Results Immediate haemostasis (<2 min) was achieved in 304/310 (98%) sites. No patients had major complications. Short-term follow-up at 3 months revealed no evidence of haematoma or fistula formation or clinical evidence of vessel occlusion. On medium-term clinical follow-up (mean follow-up of 14 +/- 12 and median of 12.4 months), no complications were seen at the venous access sites. Conclusion Preclosure of large-size femoral venous access sheath sites using the suture-mediated Perclose device is efficacious in achieving rapid haemostasis in the presence of anticoagulation in the venous site. On 1-year follow-up, there was no clinical evidence of vascular complications in the venous access sites. (c) 2012 Wiley Periodicals, Inc.