GLYCOLIPID CONTENT OF THE NUCLEAR MEMBRANE IN HYPOXIC RAT BRAIN

被引：0

作者：

Petrova, E. ^{[1
]}

Dishkelov, A. ^{[1
]}

Vasileva, E. ^{[1
]}

Gramatikova, T. ^{[1
]}

Ormandzhieva, V. ^{[1
]}

Dimitrova, S. ^{[2
]}

机构：

[1] Bulgarian Acad Sci, Inst Expt Morphol Pathol & Anthropol Museum, Sofia, Bulgaria

[2] Bulgarian Acad Sci, Space & Solar Terr Res Inst, Sofia, Bulgaria

来源：

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | 2012年 / 26卷

关键词：

glycolipids; hypoxia; sodium nitrite; nuclear subcellular fraction; rat brain;

D O I：

10.5504/50YRTIMB.2011.0014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this study, we report glycolipid changes in the nuclear subcellular fraction from hypoxic rat brains. Male Wistar rats at the age of three months were subjected to sodium nitrite-induced hypoxia. Te nuclear fraction was isolated and lipids were extracted. The glycolipid content was measured by spectrophotometry and thin-layer chromatography. In controls, gangliosides and cerebrosides were the major glycolipid classes. In the nuclear membrane of hypoxic brains, we found increased levels of total glycolipids (5.2-fold), gangliosides (4.1-fold), and cerebrosides (5.9-fold). These changes reflect the disturbances in the glycolipid turnover. Most probably they are associated with impaired energy metabolism. The accumulation of glycolipids may be interpreted as a physiological adaptive response to hypoxia.

引用

页码：77 / 79

页数：3

共 20 条

[11] Neuronal Cell Death in Neonatal Hypoxia-Ischemia [J].

Northington, Frances J. ;

Chavez-Valdez, Raul ;

Martin, Lee J. .

ANNALS OF NEUROLOGY, 2011, 69 (05) :743-758

[12]

Petrova E., 2009, JBCR S1, V2, P35

[13]

Petrova E., 2010, MED DATA, V2, P5

[14] Neonatal hypoxia-ischemia reduces ganglioside, phospholipid and cholesterol contents in the rat hippocampus [J].

Ramirez, MR ;

Muraro, F ;

Zylbersztejn, DS ;

Abel, CR ;

Arteni, NS ;

Lavinsky, D ;

Netto, CA ;

Trindade, VMT .

NEUROSCIENCE RESEARCH, 2003, 46 (03) :339-347

[15] Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1 [J].

Semenza, Gregg L. .

PHYSIOLOGY, 2009, 24 (02) :97-106

[16]

Venkov L., 1983, CONT PROBL NEUROMORP, V11, P1

[17] Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress [J].

Witt, KA ;

Mark, KS ;

Huber, J ;

Davis, TP .

JOURNAL OF NEUROCHEMISTRY, 2005, 92 (01) :203-214

[18]

Xie Y Z, 2000, Space Med Med Eng (Beijing), V13, P191

[19]

Yu RK., 2008, GLYCOSCIENCE, V2nd, P1671, DOI [DOI 10.1007/978-3-540-30429-6_41, 10.1007/978-3-540-30429-6_41]

[20]

Zaidi ZF, 2010, PAK J MED SCI, V26, P261

← 1 2 →