Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

被引：0

作者：

Kapanda, C. N. ^{[1
]}

Poupaert, J. H. ^{[1
]}

Lambert, D. M. ^{[1
]}

机构：

[1] Catholic Univ Louvain, LDRI, Med Chem Cannabinoid & Endocannabinoid Res Grp, B-1200 Brussels, Belgium

来源：

CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 14期

关键词：

Endocannabinoid hydrolases; inhibitors; design; chemical structures; inhibition mechanism; structure-activity relationships; ACID AMIDE HYDROLASE; MONOACYLGLYCEROL LIPASE INHIBITORS; CANNABINOID-RECEPTOR LIGANDS; ACTIVITY IN-VIVO; 2-ARACHIDONOYLGLYCEROL HYDROLYSIS; MOLECULAR CHARACTERIZATION; REVERSIBLE INHIBITORS; MONOGLYCERIDE LIPASE; CB1; RECEPTOR; ANANDAMIDE AMIDOHYDROLASE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.

引用

页码：1824 / 1846

页数：23

共 139 条

[81] Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
Leung, D
Hardouin, C
Boger, DL
Cravatt, BF
[J]. NATURE BIOTECHNOLOGY, 2003, 21 (06) : 687 - 691
[82] A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
Li, Weiwei
Blankman, Jacqueline L.
Cravatt, Benjamin F.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (31) : 9594 - +
[83] Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: Evidence for an unprecedented combination of potency and selectivity
Lichtman, AH
Leung, D
Shelton, CC
Saghatelian, A
Hardouin, C
Boger, DL
Cravatt, BF
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (02) : 441 - 448
[84] Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hydrolases
Long, Jonathan Z.
Jin, Xin
Adibekian, Alexander
Li, Weiwei
Cravatt, Benjamin F.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (04) : 1830 - 1842
[85] Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism
Long, Jonathan Z.
Nomura, Daniel K.
Cravatt, Benjamin F.
[J]. CHEMISTRY & BIOLOGY, 2009, 16 (07): : 744 - 753
[86] Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Long, Jonathan Z.
Li, Weiwei
Booker, Lamont
Burston, James J.
Kinsey, Steven G.
Schlosburg, Joel E.
Pavon, Francisco J.
Serrano, Antonia M.
Selley, Dana E.
Parsons, Loren H.
Lichtman, Aron H.
Cravatt, Benjamin F.
[J]. NATURE CHEMICAL BIOLOGY, 2009, 5 (01) : 37 - 44
[87] Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms
Maione, S.
Morera, E.
Marabese, I.
Ligresti, A.
Luongo, L.
Ortar, G.
Di Marzo, V.
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2008, 155 (05) : 775 - 782
[88] The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
Marrs, William R.
Blankman, Jacqueline L.
Horne, Eric A.
Thomazeau, Aurore
Lin, Yi Hsing
Coy, Jonathan
Bodor, Agnes L.
Muccioli, Giulio G.
Hu, Sherry Shu-Jung
Woodruff, Grace
Fung, Susan
Lafourcade, Mathieu
Alexander, Jessica P.
Long, Jonathan Z.
Li, Weiwei
Xu, Cong
Moeller, Thomas
Mackie, Ken
Manzoni, Olivier J.
Cravatt, Benjamin F.
Stella, Nephi
[J]. NATURE NEUROSCIENCE, 2010, 13 (08) : 951 - U67
[89] CB1 cannabinoid receptors and on-demand defense against excitotoxicity
Marsicano, G
Goodenough, S
Monory, K
Hermann, H
Eder, M
Cannich, A
Azad, SC
Cascio, MG
Gutiérrez, SO
van der Stelt, M
López-Rodríguez, ML
Casanova, E
Schütz, G
Zieglgänsberger, W
Di Marzo, V
Behl, C
Lutz, B
[J]. SCIENCE, 2003, 302 (5642) : 84 - 88
[90] Matsumoto T, 2006, PCT Int. Appl., Patent No. 2006054652

← 4 5 6 7 8 9 10 11 12 13 →