Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

被引：0

作者：

Kapanda, C. N. ^{[1
]}

Poupaert, J. H. ^{[1
]}

Lambert, D. M. ^{[1
]}

机构：

[1] Catholic Univ Louvain, LDRI, Med Chem Cannabinoid & Endocannabinoid Res Grp, B-1200 Brussels, Belgium

来源：

CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 14期

关键词：

Endocannabinoid hydrolases; inhibitors; design; chemical structures; inhibition mechanism; structure-activity relationships; ACID AMIDE HYDROLASE; MONOACYLGLYCEROL LIPASE INHIBITORS; CANNABINOID-RECEPTOR LIGANDS; ACTIVITY IN-VIVO; 2-ARACHIDONOYLGLYCEROL HYDROLYSIS; MOLECULAR CHARACTERIZATION; REVERSIBLE INHIBITORS; MONOGLYCERIDE LIPASE; CB1; RECEPTOR; ANANDAMIDE AMIDOHYDROLASE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.

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页码：1824 / 1846

页数：23

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