Regular Exercise Enhances the Immune Response Against Microbial Antigens Through Up-Regulation of Toll-like Receptor Signaling Pathways

被引：56
作者：
Zheng, Qishi [1 ,2 ]
Cui, Guangying [1 ]
Chen, Jianing [1 ]
Gao, Hainv [1 ]
Wei, Yingfeng [1 ]
Uede, Toshimitsu [3 ]
Chen, Zhi [1 ]
Diao, Hongyan [1 ]
机构：
[1] Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Di, Affiliated Hosp 1,Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Publ Phys & Art Educ, Publ Sport Ctr, Hangzhou 310003, Zhejiang, Peoples R China
[3] Hokkaido Univ, Inst Med Genet, Mol Immunol, Sapporo, Hokkaido, Japan
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2015年 / 37卷 / 02期
基金：
中国国家自然科学基金; 国家教育部博士点专项基金资助;
关键词：
Regular physical exercise; Pathogenic infection; Cytokine; Toll-like receptor; Immune response; MODERATE EXERCISE; DENDRITIC CELLS; LYMPHOCYTE; HEPATITIS; RATS; INFECTIONS; ACTIVATION; EXPRESSION; MARATHON; INNATE;
D O I：
10.1159/000430391
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Regular physical exercise can enhance resistance to many microbial infections. However, little is known about the mechanism underlying the changes in the immune system induced by regular exercise. Methods: We recruited members of a university badminton club as the regular exercise (RE) group and healthy sedentary students as the sedentary control (SC) group. We investigated the distribution of peripheral blood mononuclear cell (PBMC) subsets and functions in the two groups. Results: There were no significant differences in plasma cytokine levels between the RE and SC groups in the true resting state. However, enhanced levels of IFN-gamma, TNF-alpha, IL-6, IFN-beta and IL-12 were secreted by PBMCs in the RE group following microbial antigen stimulation, when compared to the SC group. In contrast, the levels of TNF-alpha and IL-6 secreted by PBMC in the RE group were suppressed compared with those in SC group following non-microbial antigen stimulation (concanavalin A or alpha-galactosylceramide). Furthermore, PBMC expression of TLR2, TLR7 and MyD88 was significantly increased in the RE group in response to microbial antigen stimulation. Conclusion: Regular exercise enhances immune cell activation in response to pathogenic stimulation leading to enhanced cytokine production mediated via the TLR signaling pathways. Copyright (C) 2015 S. Karger AG, Basel
引用
收藏
页码：735 / 746
页数：12
相关论文
共 40 条
[1]   High IFN-gamma and TNF production by peripheral NK cells of Colombian patients with different clinical presentation of Plasmodium falciparum [J].
Agudelo, Olga ;
Bueno, Julio ;
Villa, Andres ;
Maestre, Amanda .
MALARIA JOURNAL, 2012, 11
[2]   FSL-1 Induces MMP-9 Production through TLR-2 and NF-κB/AP-1 Signaling Pathways in Monocytic THP-1 Cells [J].
Ahmad, Rasheed ;
Shihab, Puthiyaveetil Kochumon ;
Jasem, Sara ;
Behbehani, Kazem .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2014, 34 (03) :929-942
[3]   In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis [J].
Bulau, Ana-Maria ;
Fink, Michaela ;
Maucksch, Christof ;
Kappler, Roland ;
Mayr, Doris ;
Wagner, Kai ;
Bufler, Philip .
THESCIENTIFICWORLDJOURNAL, 2011, 11 :2480-2490
[4]   Impact of exercise training on redox signaling in cardiovascular diseases [J].
Campos, Juliane C. ;
Gomes, Katia M. S. ;
Ferreira, Julio C. B. .
FOOD AND CHEMICAL TOXICOLOGY, 2013, 62 :107-119
[5]   Heterologous T Cells Can Help Restore Function in Dysfunctional Hepatitis C Virus Nonstructural 3/4A-Specific T Cells during Therapeutic Vaccination [J].
Chen, Antony ;
Ahlen, Gustaf ;
Brenndorfer, Erwin D. ;
Brass, Anette ;
Holmstrom, Fredrik ;
Chen, Margaret ;
Soderholm, Jonas ;
Milich, David R. ;
Frelin, Lars ;
Sallberg, Matti .
JOURNAL OF IMMUNOLOGY, 2011, 186 (09) :5107-5118
[6]   Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury [J].
de Araujo, Carla C. ;
Silva, Johnatas D. ;
Samary, Cynthia S. ;
Guimaraes, Isabela H. ;
Marques, Patricia S. ;
Oliveira, Gisele P. ;
do Carmo, Luana G. R. R. ;
Goldenberg, Regina C. ;
Bakker-Abreu, Ilka ;
Diaz, Bruno L. ;
Rocha, Nazareth N. ;
Capelozzi, Vera L. ;
Pelosi, Paolo ;
Rocco, Patricia R. M. .
JOURNAL OF APPLIED PHYSIOLOGY, 2012, 112 (07) :1206-1214
[7]   Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production [J].
Diao, H ;
Kohanawa, M .
INFECTION AND IMMUNITY, 2005, 73 (06) :3745-3748
[8]   Hypertensive men who exercise regularly have lower rate of cardiovascular mortality [J].
Engström, G ;
Hedblad, B ;
Janzon, L .
JOURNAL OF HYPERTENSION, 1999, 17 (06) :737-742
[9]   Interferon-α in the generation of monocyte-derived dendritic cells: recent advances and implications for dermatology [J].
Farkas, A. ;
Kemeny, L. .
BRITISH JOURNAL OF DERMATOLOGY, 2011, 165 (02) :247-254
[10]   Uptake and Intracellular Trafficking of Superantigens in Dendritic Cells [J].
Ganem, Maria B. ;
De Marzi, Mauricio C. ;
Fernandez-Lynch, Maria J. ;
Jancic, Carolina ;
Vermeulen, Monica ;
Geffner, Jorge ;
Mariuzza, Roy A. ;
Fernandez, Marisa M. ;
Malchiodi, Emilio L. .
PLOS ONE, 2013, 8 (06)
1234