Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese

被引:63
作者
Tomiyama, Hirofumi [1 ]
Kohro, Takahide [2 ]
Higashi, Yukihito [3 ]
Takase, Bonpei [4 ]
Suzuki, Toru [5 ]
Ishizu, Tomoko [6 ]
Ueda, Shinichiro [7 ]
Yamazaki, Tsutomu [8 ]
Furumoto, Tomoo [9 ]
Kario, Kazuomi [10 ]
Inoue, Teruo [11 ]
Koba, Shinji [12 ]
Watanabe, Kentaro [13 ]
Takemoto, Yasuhiko [14 ]
Hano, Takuzo [15 ]
Sata, Masataka [16 ]
Ishibashi, Yutaka [17 ]
Node, Koichi [18 ]
Maemura, Koji [19 ]
Ohya, Yusuke [20 ]
Furukawa, Taiji [21 ]
Ito, Hiroshi [22 ]
Ikeda, Hisao [23 ]
Yamashina, Akira [1 ]
机构
[1] Tokyo Med Univ, Dept Cardiol, Tokyo 1600023, Japan
[2] Jichi Med Univ, Sch Med, Dept Clin Informat, Shimotsuke, Tochigi, Japan
[3] Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Physiol & Med, Hiroshima, Japan
[4] Natl Def Med Coll, Res Inst, Div Biomed Engn, Saitama, Japan
[5] Univ Leicester, Cardiovasc Med, Leicester, Leics, England
[6] Univ Tsukuba, Div Cardiovasc, Inst Clin Med, Ibaraki, Japan
[7] Univ Ryukyus, Sch Med, Dept Clin Pharmacol & Therapeut, Okinawa, Japan
[8] Univ Tokyo, Fac Med, Dept Clin Epidemiol & Syst, Tokyo 113, Japan
[9] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido 060, Japan
[10] Jichi Med Univ, Sch Med, Div Cardiovasc Med, Shimotsuke, Tochigi, Japan
[11] Dokkyo Med Univ, Dept Cardiovasc Med, Mibu, Tochigi, Japan
[12] Showa Univ, Sch Med, Dept Med, Div Cardiol, Tokyo 142, Japan
[13] Yamagata Univ, Sch Med, Dept Neurol Hematol Metaboism Endocrinol & Diabet, Yamagata 99023, Japan
[14] Osaka City Univ, Grad Sch Med, Dept Internal Med & Cardiol, Osaka 558, Japan
[15] Wakayama Med Univ, Postgrad Med Sch, Dept Med Educ & Populat Based Med, Wakayama, Japan
[16] Univ Tokushima, Grad Sch, Dept Cardiovasc Med, Inst Hlth Biosci, Tokushima 770, Japan
[17] Shimane Univ, Fac Med, Dept Gen Med, Izumo, Shimane, Japan
[18] Saga Univ, Dept Cardiovasc & Renal Med, Saga 840, Japan
[19] Nagasaki Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, Course Med & Dent Sci, Nagasaki 852, Japan
[20] Univ Ryukyus, Dept Internal Med 3, Okinawa, Japan
[21] Teikyo Univ, Sch Med, Dept Internal Med, Tokyo 173, Japan
[22] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Med, Okayama 7008530, Japan
[23] Kurume Univ, Sch Med, Dept Med, Div Cardiovasc Med, Kurume, Fukuoka 830, Japan
关键词
Endothelial function; Reference value; Standardization; Reliability; FLOW-MEDIATED DILATION; INCIDENT CARDIOVASCULAR EVENTS; BRACHIAL-ARTERY REACTIVITY; RISK-FACTORS; VASODILATATION; REPRODUCIBILITY; MULTICENTER; DILATATION; VARIABILITY; PREDICTION;
D O I
10.1016/j.atherosclerosis.2015.08.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: For the standardization of flow-mediated vasodilatation (FMD) assessment as a clinical tool, validation of its reliability across multiple institutions and the establishment of normal/reference values based on reliable data from multiple institutions are needed. Methods and results: In Study 1, assessment of FMD (scan recording and analysis) using an ultrasonographic semi-automatic measuring system (sFMD) was conducted at 18 participating institutions (sFMDINST) (n = 981). All of the brachial arterial scans were also analyzed at a core laboratory (sFMD-COLB). After 111 subjects with inadequate sFMD recordings were excluded (n = 880), the correlation between the sFMD-INST and sFMD-COLB improved from R = 0.725 to R = 0.838 (p < 0.001). In Study 2, based on good-quality sFMD data obtained from 6660 subjects without cardiovascular disease (CVD) and 729 subjects with CVD from 27 institutions, reference values of sFMD are proposed by the Framingham risk score (FRS)-based risk categories and according to gender and age. The receiver-operating characteristic curve analysis revealed a significant power of sFMD values in reference ranges to discriminate between subjects with and without CVD (e.g., area under curve = 0.64 in the FRS-low risk group). Conclusions: When the analysis was limited to cases with clear sFMD recordings, the reliability of the sFMD assessment (scan and its analysis) conducted in individual institutions appeared to be acceptable. Reference sFMD values (lower cuff occlusion) for the Japanese population are proposed based on reliable data derived from multiple institutions, and the reference values may identify patients without advanced vascular damage. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
引用
收藏
页码:433 / 442
页数:10
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