Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D

被引：114
作者：
Santos, Edorta [1 ,2 ]
Hernandez, Rosa M. [1 ,2 ]
Luis Pedraz, Jose [1 ,2 ]
Orive, Gorka [1 ,2 ]
机构：
[1] Univ Basque Country, Sch Pharm, NanoBioCel Grp, Lab Pharmaceut, Vitoria, Spain
[2] Biomed Res Networking Ctr Bioengn Biomat & Nanome, Vitoria, Spain
来源：
TRENDS IN BIOTECHNOLOGY | 2012年 / 30卷 / 06期
关键词：
biomaterial; 3D scaffolds; cell encapsulation; artificial ECM; tissue engineering; regenerative medicine; POLY(ETHYLENE GLYCOL) HYDROGELS; HYALURONIC-ACID HYDROGELS; ENDOTHELIAL GROWTH-FACTOR; EXTRACELLULAR-MATRIX; BIOACTIVE HYDROGELS; FUNCTIONAL REPAIR; PEG HYDROGELS; DELIVERY; BIOMATERIALS; DIFFERENTIATION;
D O I：
10.1016/j.tibtech.2012.03.005
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recreating the most critical aspects of the native extracellular matrix (ECM) is fundamental to understand and control the processes regulating cell fate and cell function. From the ill-defined complexity to the controlled simplicity, we discuss the different strategies that are being carried out by scientists worldwide to achieve the latest advances in the sophistication of three-dimensional (3D) scaffolds, stressing their impact on cell biology, tissue engineering and regenerative medicine. Synthetic and naturally derived polymers like polyethylene glycol, alginate, agarose, etc., together with micro- and nano-fabrication techniques are allowing the creation of 3D models where biophysical and biochemical variables can be modified with high precision, orthogonality and even in real-time.
引用
收藏
页码：331 / 341
页数：11
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