Multisubunit RNA polymerases

被引：194

作者：

Cramer, P ^{[1
]}

机构：

[1] Univ Munich, Inst Biochem, Gene Ctr, D-81377 Munich, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(02)00294-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.

引用

页码：89 / 97

页数：9

共 50 条

[1] Mutational analysis of β′260-309, a σ70 binding site located on Escherichia coli core RNA polymerase [J].

Arthur, TM ;

Anthony, LC ;

Burgess, RR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :23113-23119

[2] Localization of a σ70 binding site on the N terminus of the Escherichia coli RNA polymerase β′ subunit [J].

Arthur, TM ;

Burgess, RR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (47) :31381-31387

[3] The orientation of DNA in an archaeal transcription initiation complex [J].

Bartlett, MS ;

Thomm, M ;

Geiduschek, EP .

NATURE STRUCTURAL BIOLOGY, 2000, 7 (09) :782-785

[4] STRUCTURAL BASIS FOR THE 3'-5' EXONUCLEASE ACTIVITY OF ESCHERICHIA-COLI DNA-POLYMERASE-I - A 2 METAL-ION MECHANISM [J].

BEESE, LS ;

STEITZ, TA .

EMBO JOURNAL, 1991, 10 (01) :25-33

[5] Identification of RNA polymerase β′ subunit segment contacting the melted region of the lacUV5 promoter [J].

Brodolin, K ;

Mustaev, A ;

Severinov, K ;

Nikiforov, V .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) :3661-3666

[6]

BUSHNELL DA, 2001, STRUCTURE FOLD DES, V9, pR3

[7] Structural mechanism for rifampicin inhibition of bacterial RNA polymerase [J].

Campbell, EA ;

Korzheva, N ;

Mustaev, A ;

Murakami, K ;

Nair, S ;

Goldfarb, A ;

Darst, SA .

CELL, 2001, 104 (06) :901-912

[8] HUMAN RPB5, A SUBUNIT SHARED BY EUKARYOTIC NUCLEAR-RNA POLYMERASES, BINDS HUMAN HEPATITIS-B VIRUS X-PROTEIN AND MAY PLAY A ROLE IN X-TRANSACTIVATION [J].

CHEONG, JH ;

YI, MK ;

LIN, Y ;

MURAKAMI, S .

EMBO JOURNAL, 1995, 14 (01) :143-150

[9] Architecture of RNA polymerase II and implications for the transcription mechanism [J].

Cramer, P ;

Bushnell, DA ;

Fu, JH ;

Gnatt, AL ;

Maier-Davis, B ;

Thompson, NE ;

Burgess, RR ;

Edwards, AM ;

David, PR ;

Kornberg, RD .

SCIENCE, 2000, 288 (5466) :640-649

[10] Structural basis of transcription:: RNA polymerase II at 2.8 Ångstrom resolution [J].

Cramer, P ;

Bushnell, DA ;

Kornberg, RD .

SCIENCE, 2001, 292 (5523) :1863-1876

← 1 2 3 4 5 →