Uterine size and ovarian size in adolescents with functional hypothalamic amenorrhoea

被引:8
作者
Bumbuliene, Zana [1 ]
Klimasenko, Jelena [1 ]
Sragyte, Diana [1 ]
Zakareviciene, Jolita [1 ]
Drasutiene, Grazina [1 ]
机构
[1] Vilnius Univ, Fac Med, Clin Obstet & Gynaecol, LT-08406 Vilnius, Lithuania
关键词
NORMAL GIRLS; BODY-FAT; PUBERTY; ULTRASONOGRAPHY; WOMEN;
D O I
10.1136/archdischild-2014-307504
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Introduction Functional hypothalamic amenorrhoea (FHA) is a condition characterised by the absence of menses due to suppression of the hypothalamic-pituitary-ovarian axis. Objective The purpose of the study was to estimate uterine and ovarian sizes in adolescents with FHA and to compare these results with findings in peers having regular menstrual cycles. Design Prospective case-controlled study. Settings Vilnius University Hospital Santariskiu Klinikos, Lithuania. Patients Lithuanian adolescents-45 with FHA and 40 comparison group participants. Main outcome measures We assessed ultrasound measurements of internal reproductive organs, levels of luteinising hormone, follicle-stimulating hormone, prolactin, oestradiol and calculated body mass index (BMI). Results The mean age of the participants was 16.3 +/- 1.2 years, the mean age after menarche-3.6 years. In adolescents with FHA the BMI was 17.8 +/- 1.8 kg/m(2) and 20.4 +/- 1.4 kg/m(2) in the comparison group, p< 0.001. The uterine volume (14.7 +/- 6.3 cm(3) vs 31.7 +/- 10.6 cm(3), p< 0.001), cervical length (2.3 +/- 0.4 cm vs 2.6 +/- 0.5 cm, p= 0.03), volume of both ovaries (9.3 +/- 3.6 cm(3) vs 13.8 +/- 4.3 cm(3), p< 0.001) and levels of LH (2.70 +/- 2.59 vs 6.01 +/- 2.44, p< 0.001) were significantly lower in girls with FHA. A significantly positive correlation between volume of uterus and levels of LH (r= 0.415; p< 0.001) was found. We identified a positive correlation between uterine volume, uterine corpus length, cervical length, ovarian volume and weight, BMI. Conclusions In adolescents with FHA the dimensions of uterus and ovaries were smaller than in girls having regular menstrual cycles. Our study confirmed the influence of oestrogen on uterus size: oestrogen deficiency causes a reduction in uterine size. Uterine size and ovarian size correlate positively with BMI.
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页码:948 / 951
页数:4
相关论文
共 18 条
  • [1] [Anonymous], 1986, Journal of Adolescent Health, V7, P236, DOI DOI 10.1016/S0197-0070(86)80015-8
  • [2] Sonographic Assessment of Uterine and Ovarian Development in Normal Girls Aged 1 to 12 Years
    Badouraki, Maria
    Christoforidis, Athanasios
    Economou, Ippoliti
    Dimitriadis, Athanassios S.
    Katzos, George
    [J]. JOURNAL OF CLINICAL ULTRASOUND, 2008, 36 (09) : 539 - 544
  • [3] Long-term follow-up of functional hypothalamic amenorrhea and prognostic factors
    Falsetti, L
    Gambera, A
    Barbetti, L
    Specchia, C
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (02) : 500 - 505
  • [4] BODY-FAT, MENARCHE, FITNESS AND FERTILITY
    FRISCH, RE
    [J]. HUMAN REPRODUCTION, 1987, 2 (06) : 521 - 533
  • [5] Functional Hypothalamic Amenorrhea
    Gordon, Catherine M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (04) : 365 - 371
  • [6] Ovarian and uterine findings in pelvic sonography - Comparison between prepubertal girls, girls with isolated thelarche, and girls with central precocious puberty
    Herter, LD
    Golendziner, E
    Flores, JAM
    Moretto, M
    Di Domenico, K
    Becker, E
    Spritzer, PM
    [J]. JOURNAL OF ULTRASOUND IN MEDICINE, 2002, 21 (11) : 1237 - 1246
  • [7] Khadilkar VV, 2006, INDIAN PEDIATR, V43, P625
  • [8] Lai KY, 1994, ARCH DIS CHILD, V71, P288
  • [9] Stress-associated or functional hypothalamic amenorrhea in the adolescent
    Liu, James H.
    Bill, Arthur H.
    [J]. MENSTRUAL CYCLE AND ADOLESCENT HEALTH, 2008, 1135 : 179 - 184
  • [10] Functional hypothalamic amenorrhea: Current view on neuroendocrine aberrations
    Meczekalski, Blazej
    Podfigurna-Stopa, Agnieszka
    Warenik-Szymankiewicz, Alina
    Genazzan, Andrea Riccardo
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 2008, 24 (01) : 4 - 11