Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts

被引：216

作者：

Magistri, Marco ^{[1
,2
]}

Faghihi, Mohammad Ali ^{[1
,2
]}

St Laurent, Georges, III ^{[3
]}

Wahlestedt, Claes ^{[1
,2
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Ctr Therapeut Innovat, Miami, FL 33136 USA

[3] St Laurent Inst, Cambridge, MA 02139 USA

来源：

TRENDS IN GENETICS | 2012年 / 28卷 / 08期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

antisense RNA; epigenetics; transcriptome; chromatin; ncRNAs; NATs; HUMAN GENOME; EPIGENETIC REGULATION; HISTONE MODIFICATION; GENE-EXPRESSION; GROUP PROTEINS; BINDING-SITES; X-CHROMOSOME; MECHANISMS; IDENTIFICATION; REVEAL;

D O I：

10.1016/j.tig.2012.03.013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the decade following the publication of the Human Genome, noncoding RNAs (ncRNAs) have reshaped our understanding of the broad landscape of genome regulation. During this period, natural antisense transcripts (NATs), which are transcribed from the opposite strand of either protein or non-protein coding genes, have vaulted to prominence. Recent findings have shown that NATs can exert their regulatory functions by acting as epigenetic regulators of gene expression and chromatin remodeling. Here, we review recent work on the mechanisms of epigenetic modifications by NATs and their emerging role as master regulators of chromatin states. Unlike other long ncRNAs, antisense RNAs usually regulate their counterpart sense mRNA in cis by bridging epigenetic effectors and regulatory complexes at specific genomic loci. Understanding the broad range of effects of NATs will shed light on the complex mechanisms that regulate chromatin remodeling and gene expression in development and disease.

引用

页码：389 / 396

页数：8

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