Parametric imaging of myocardial viability using 15O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR

被引：11

作者：

de Haan, Stefan ^{[1
,4
]}

Harms, Hendrik J. ^{[2
,4
]}

Lubberink, Mark ^{[2
,4
]}

Allaart, Cornelis P. ^{[1
,4
]}

Danad, Ibrahim ^{[1
,4
]}

Chen, Weena J. Y. ^{[3
,4
]}

Diamant, Michaela ^{[3
,4
]}

van Rossum, Albert C. ^{[1
,4
]}

Iida, Hidehiro ^{[5
]}

Lammertsma, Adriaan A. ^{[2
,4
]}

Knaapen, Paul ^{[1
,4
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Nucl Med & PET Res, NL-1081 HV Amsterdam, Netherlands

[3] Ctr Diabet, Dept Internal Med, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res ICaR VU, NL-1081 HV Amsterdam, Netherlands

[5] Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Invest Radiol, Osaka, Japan

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2012年 / 39卷 / 08期

关键词：

PET/CT; CMR; Perfusable tissue index; Late gadolinium enhancement; POSITRON-EMISSION-TOMOGRAPHY; PERFUSABLE TISSUE INDEX; ISCHEMIC-HEART-DISEASE; CORONARY-ARTERY-DISEASE; BLOOD-FLOW; VENTRICULAR DYSFUNCTION; MAGNETIC-RESONANCE; O-15-WATER; REVASCULARIZATION; QUANTIFICATION;

D O I：

10.1007/s00259-012-2134-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The perfusable tissue index (PTI) is a marker of myocardial viability. Recent technological advances have made it possible to generate parametric PTI images from a single [O-15]H2O PET/CT scan. The purpose of this study was to validate these parametric PTI images. The study population comprised 46 patients with documented or suspected coronary artery disease who were studied with [O-15]H2O PET and late gadolinium-enhanced (LGE) cardiac magnetic resonance imaging (CMR). Of the 736 myocardial segments included, 364 showed some degree of LGE. PTI and perfusable tissue fraction (PTF) diminished with increasing LGE. The areas under the curve of the PTI and PTF, used to predict (near) transmural LGE on CMR, were 0.86 and 0.87, respectively. Optimal sensitivity and specificity were 91 % and 73 % for PTI and 69 % and 87 % for PTF, respectively. PTI and PTF assessed with a single [O-15]H2O scan can be utilized as markers of myocardial viability in patients with coronary artery disease.

引用

页码：1240 / 1245

页数：6

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