RETRACTED: Effect of nanostructure on osteoinduction of porous biphasic calcium phosphate ceramics (Retracted article. See vol. 9, pg. 7070, 2013)

被引：33
作者：
Li, Bo [1 ,2 ]
Liao, Xiaoling [1 ]
Zheng, Li [2 ]
Zhu, Xiangdong [2 ]
Wang, Zhe [2 ]
Fan, Hongsong [2 ]
Zhang, Xingdong [2 ]
机构：
[1] Chongqing Univ Sci & Technol, Inst Biomat & Living Cell Imaging Technol, Sch Met & Mat Engn, Chongqing 401331, Peoples R China
[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
来源：
ACTA BIOMATERIALIA | 2012年 / 8卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Nanotopography; Bone tissue engineering; Calcium phosphate; Protein adsorption; Gene expression; HYDROXYAPATITE NANOCRYSTALS; CELLULAR BIOCOMPATIBILITY; CARBONATED HYDROXYAPATITE; PROTEIN ADSORPTION; BONE SUBSTITUTE; 2.45; GHZ; KINDS; ALUMINA; MICROENVIRONMENT; BIOMATERIALS;
D O I：
10.1016/j.actbio.2012.06.021
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In order to evaluate the effect of the nanostructure of calcium phosphate ceramics on osteoinductive potential, porous biphasic calcium phosphate (BCP) ceramics with a nano- or submicron structure were prepared via microwave sintering and compared to conventional BCP ceramics. The selective protein adsorption of bovine serum albumin and lysozyme (LSZ) and the osteogenic differentiation of human mesenchymal stem cells in vitro was investigated. Porous BCP nanoceramics showed higher ability to adsorb proteins, especially low molecular weight protein of LSZ, than conventional BCP ceramics, and the BCP nanoceramics promoted bone sialoprotein expression more than conventional BCP did. Further in vivo study to investigate ectopic bone formation and bone repair efficiency proved the highly osteoinductive potential of nanostructured BCP ceramics. The results suggest that nanostructured BCP ceramics have the potential to become a new generation of bioceramics for bone tissue engineering grafts. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：3794 / 3804
页数：11
相关论文
共 40 条
[31]   THE MORPHOGENESIS OF BONE IN REPLICAS OF POROUS HYDROXYAPATITE OBTAINED FROM CONVERSION OF CALCIUM-CARBONATE EXOSKELETONS OF CORAL [J].
RIPAMONTI, U .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1991, 73A (05) :692-703
[32]   The Effect of Surface Nanometre-Scale Morphology on Protein Adsorption [J].
Scopelliti, Pasquale Emanuele ;
Borgonovo, Antonio ;
Indrieri, Marco ;
Giorgetti, Luca ;
Bongiorno, Gero ;
Carbone, Roberta ;
Podesta, Alessandro ;
Milani, Paolo .
PLOS ONE, 2010, 5 (07)
[33]   Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin [J].
Webster, TJ ;
Schadler, LS ;
Siegel, RW ;
Bizios, R .
TISSUE ENGINEERING, 2001, 7 (03) :291-301
[34]   Bone morphogenetic protein and ceramic-induced osteogenesis [J].
Yuan, HP ;
Zou, P ;
Yang, ZJ ;
Zhang, XD ;
De Bruijn, JD ;
De Groot, K .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1998, 9 (12) :717-721
[35]   A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics [J].
Yuan, HP ;
Kurashina, K ;
de Bruijn, JD ;
Li, YB ;
de Groot, K ;
Zhang, XD .
BIOMATERIALS, 1999, 20 (19) :1799-1806
[36]   Osteoinductive ceramics as a synthetic alternative to autologous bone grafting [J].
Yuan, Huipin ;
Fernandes, Hugo ;
Habibovic, Pamela ;
de Boer, Jan ;
Barradas, Ana M. C. ;
de Ruiter, Ad ;
Walsh, William R. ;
van Blitterswijk, Clemens A. ;
de Bruijn, Joost D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) :13614-13619
[37]  
Zhang X., 1991, Bioceramics and the Human Body, P408
[38]   Synthesis and cellular biocompatibility of two kinds of HAP with different nanocrystal morphology [J].
Zhao, Yantao ;
Zhang, Yurnei ;
Ning, Fang ;
Guo, Dagang ;
Xu, Zhixuan .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2007, 83B (01) :121-126
[39]   Competitive adsorption of bovine serum albumin and lysozyme on characterized calcium phosphates by polyacrylamide gel electrophoresis method [J].
Zhu, X. D. ;
Fan, H. S. ;
Zhao, C. Y. ;
Lu, J. ;
Ikoma, T. ;
Tanaka, J. ;
Zhang, X. D. .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2007, 18 (11) :2243-2249
[40]   Effect of phase composition and microstructure of calcium phosphate ceramic particles on protein adsorption [J].
Zhu, X. D. ;
Zhang, H. J. ;
Fan, H. S. ;
Li, Wei ;
Zhang, X. D. .
ACTA BIOMATERIALIA, 2010, 6 (04) :1536-1541
1234